Results 71 to 80 of about 45,932 (320)
Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction
Advanced Science, EarlyView.Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan +17 more
wiley +1 more source
Atheroprotective Effects of Glycyrrhiza glabra L.
Molecules, 2022 Cardiovascular diseases associated with atherosclerosis are the major cause of death in developed countries. Early prevention and treatment of atherosclerosis are considered to be an important aspect of the therapy of cardiovascular disease. Preparations
Yuliya V. Markina +6 more
doaj +1 more source
, 2005 Glycyrrhizin is a triterpenoid saponin found in Glychyrrhiza glabra (licorice). Chemically, glycyrrhizin is a sulphated polysaccharide. It is considered to the active constituent of the drug and the standardization of licorice is based on glycyrrhizin ...
Singh, Amrit Pal
core +1 more source
Ligand‐Induced Electronic Response Enables Predictive QM/MM Simulations
Advanced Science, EarlyView.Quantum mechanics/molecular mechanics (QM/MM) simulations are powerful tools for modeling complex molecular systems; however, their predictability has been constrained by the ambiguous definition of the QM region. An electronically informed protocol is introduced that defines QM regions by quantifying guest‐induced orbital shifts and charge ...
Nichika Ozawa +2 more
wiley +1 more source
Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. [PDF]
, 2011 The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase.
Cao, Rong +7 more
core +4 more sources
British Journal of Clinical Pharmacology, EarlyView.Aims Vutiglabridin (HSG4112) is a novel drug under clinical development for antiobesity treatment. This study aimed to evaluate the pharmacokinetics (PKs) and safety of vutiglabridin after multiple oral administrations in healthy Korean female and obese subjects and explore short‐term pharmacodynamic (PD) responses.
Sooyoun Lee +5 more
wiley +1 more source
, 2010 The aim of this study was to find out how many and which of the herbs used for horses that have been scientifically studied with results to justify the use.
Fors, Maria
core +1 more source
Distinctive rings in the 21 cm signal of the epoch of reionization
, 2011 It is predicted that sources emitting UV radiation in the Lyman band during the epoch of reionization (EoR) showed a series of discontinuities in their Ly-alpha flux radial profile as a consequence of the thickness of the Lyman line series in the ...
B. Semelin +39 more
core +2 more sources
, 2004 Collectively, plants contain several different families of natural products among which are compounds with weak estrogenic or antiestrogenic activity toward mammals.
Adlercreutz H +37 more
core +1 more source
Current Issues in Molecular Biology, 2021 Melanin is a brown or black pigment that protects skin from ultraviolet radiation and reactive oxygen species (ROS). However, overproduction of melanin is associated with lentigines, melasma, freckles and skin cancer. Licorice has shown antioxidant, anti-
Min Hye Kang +6 more
doaj +1 more source