Results 91 to 100 of about 60,981 (267)

Associations Between Life's Essential 8 and Insulin Resistance Among Nondiabetic Adults

Journal of the American Heart Association
Background Insulin resistance (IR) is closely linked to cardiometabolic diseases. Preventing and improving IR in nondiabetic populations is critically important. We aimed to investigate the relationship between Life's Essential 8 (LE8), the latest tool from the American Heart Association quantifying cardiovascular health, and ...
Shuo Pang, Yue Wang, Shuaifeng Sun, Shen Wang, Fadong Li, Wenxin Zhao, Xiaofan Wu   +6 more
openaire   +3 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Associations between asthma and Life’s Essential 8: a cross-sectional study

Frontiers in Medicine
BackgroundAsthma is a serious respiratory disease attributed to multiple factors. The Life’s Essential 8 (LE8), introduced by the American Heart Association, aims to improve and maintain cardiovascular health. However, the correlation between LE8 components and asthma remains unclear.
Jiao Xu, Jianlei Tang
openaire   +3 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Race and Ethnicity Disparities in Life’s Essential 8 Among Ever‐Pregnant Adults in the United States: The National Health and Nutrition Examination Survey 2011 to 2020

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiometabolic conditions are among the leading causes of maternal mortality in the United States. The American Heart Association’s Life’s Essential 8 provides an actionable summary measure for assessing cardiovascular health.
Khadijat Adeleye, Tosin Tomiwa, Yaa Adoma Kwapong, Ellen Boakye, Oluwalonimi Adebowale, Brenda Owusu, Ruth‐Alma Turkson‐Ocran, Yvonne Commodore‐Mensah, Oluwabunmi Ogungbe   +8 more
doaj   +1 more source

Association between Life’s essential 8 and mortality among individuals with hypertension

Scientific Reports
The "Life's Essential 8" (LE8) score is an assessment of cardiovascular health recently introduced by the American Heart Association. This study aimed to explore the correlation of the total LE8 score and its individual metrics with all-cause and cardiovascular disease (CVD) mortality in patients with hypertension.
Min Lin, Xiongbiao Lin, Wenwen Chen, Feng Huang   +3 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Association between life’s essential 8 and periodontitis: a population-based study

BMC Oral Health
Abstract Background The American Heart Association has developed a novel cardiovascular health indicator called Life’s Essential 8 (LE8). However, no one has reported using LE8 to assess periodontitis. This study aimed to investigate the association between LE8 and periodontitis in American adults.
XingJin Chen, JiangLing Sun, ChongWen Zeng, FuQian Jin, Shu Ma, Jukun Song, Zhu Chen   +6 more
openaire   +3 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Cardiovascular Health, Genetic Susceptibility, and the Risk of Incident Autoimmune Disorders in the UK Biobank: A Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Autoimmune diseases are closely linked to cardiovascular diseases. This study aimed to assess the relationship between cardiovascular health (CVH) defined by Life's Essential 8 (LE8), genetic predisposition, and the risk of 19 autoimmune ...
Lijin Lin, Yuanjun Shan, Fang Lei, Jianqing Zhang, Li Zhang, Xiao‐Jing Zhang, Wenlin Yao, Zhi‐Gang She, Hongliang Li   +8 more
doaj   +1 more source