Results 111 to 120 of about 10,008,519 (256)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Association between Life’s essential 8 and mortality among individuals with hypertension

Scientific Reports
The "Life's Essential 8" (LE8) score is an assessment of cardiovascular health recently introduced by the American Heart Association. This study aimed to explore the correlation of the total LE8 score and its individual metrics with all-cause and cardiovascular disease (CVD) mortality in patients with hypertension.
Min Lin, Xiongbiao Lin, Wenwen Chen, Feng Huang   +3 more
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Life's a Dream (la Vida Es Sueño)

Intro -- Contents -- Preface -- Introduction -- Translator's Notes -- Suggestions for Directors -- Selected Bibliography -- Life's a Dream: A Prose Translation -- Cast of Characters -- Act 1 -- Act 2 -- Act 3 -- GlossaryDescription based on publisher ...
Kidd, Michael., Calderón de la Barca, Pedro.   +1 more
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Association between Life's Simple 7 and life's essential 8 with all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome population

Aims: This study compares the associations of Life's Simple 7 (LS7) and Life's Essential 8 (LE8) with all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic (CKM) syndrome populations.
Tang, Tielong, Borné, Yan, Zhu, Pingyu, Yin, Shan, Yang, Zhenzhen, Yan, Shuang   +5 more
core   +1 more source

Life’s Essential 8 predicts the risk of periodontitis: A nomogram

Abstract Background: Life’s Essential 8 (LE8), a metric to quantify cardiovascular health, comprises eight elements of health behaviours and lifestyles. There is an interest to understand the distinct effects of individual LE8 elements on periodontal health and whether LE8 predict the risk of periodontitis.
Linxu Guo, Zhixin Luo, Ke Deng, An Li, Mi Du   +4 more
openaire   +1 more source

Association between life’s essential 8 and periodontitis: a population-based study

BMC Oral Health
Abstract Background The American Heart Association has developed a novel cardiovascular health indicator called Life’s Essential 8 (LE8). However, no one has reported using LE8 to assess periodontitis. This study aimed to investigate the association between LE8 and periodontitis in American adults.
XingJin Chen, JiangLing Sun, ChongWen Zeng, FuQian Jin, Shu Ma, Jukun Song, Zhu Chen   +6 more
openaire   +3 more sources

Association of Socioeconomic Status With Life's Essential 8 in the National Health and Nutrition Examination Survey: Effect Modification by Sex

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Higher scores for the American Heart Association Life's Essential 8 (LE8) metrics, blood pressure, cholesterol, glucose, body mass index, physical activity, smoking, sleep, and diet, are associated with lower risk of chronic disease ...
Amaris Williams, Timiya S. Nolan, Jacsen Luthy, LaPrincess C. Brewer, Robin Ortiz, Kartik K. Venkatesh, Eduardo Sanchez, Guy N. Brock, Saira Nawaz, Jennifer A. Garner, Daniel M. Walker, Darrell M. Gray, Joshua J. Joseph   +12 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source