Results 131 to 140 of about 10,008,519 (256)

Life’s Essential 8 and Mortality in US Adults With Obesity: A Cohort Study

Endocrine Practice
This study evaluates the relationship between the Life's Essential 8 (LE8) scoring system and all-cause and cause-specific mortality among obese individuals using National Health and Nutrition Examination Survey data.Data from 9143 obese participants (BMI ≥30 kg/m2) collected between 2005 and 2018 were analyzed.
Xiaoqiang Liu, Yingxuan Huang, Chanchan Lin, Xinqi Chen, Yisen Huang, Xinda Wang, Yingyi Li, Yubin Wang   +7 more
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Associations between asthma and Life’s Essential 8: a cross-sectional study

Frontiers in Medicine
BackgroundAsthma is a serious respiratory disease attributed to multiple factors. The Life’s Essential 8 (LE8), introduced by the American Heart Association, aims to improve and maintain cardiovascular health. However, the correlation between LE8 components and asthma remains unclear.
Jiao Xu, Jianlei Tang
openaire   +3 more sources

Associations between Life's Essential 8 and risks of all-cause and cardiovascular mortality in cancer survivors: A prospective cohort study from NHANES

Heliyon
Background: Life's Essential 8 (LE8), an indicator of cardiovascular health (CVH), can predict overall and cardiovascular mortality in the general population. Considering that cancer survivors have a higher risk of cardiovascular disease (CVD), our study
Wen Liu, Jia Wang, Miaomiao Wang, Huimin Hou, Xin Ding, Miao Wang, Ming Liu   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Association of change in cardiovascular health based on life's essential 8 with incident cardiovascular disease

Objective: To evaluate whether and to what extent changes in cardiovascular health (CVH) based on life's essential 8 (LE8) are associated with incident cardiovascular disease (CVD). Methods: A total of 7,194 participants were derived from UK Biobank. CVH
Chao Song, Xunjie Cheng, Yongping Bai
core   +1 more source

Food Insecurity and Ideal Cardiovascular Health Risk Factors Among US Adolescents

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Food insecurity, a social and economic condition of limited availability of healthy food, is a risk factor for adverse cardiovascular health outcomes among adults; few studies have been conducted in adolescents.
Nour M. Hammad, Julia A. Wolfson, Sarah D. de Ferranti, Walter C. Willett, Cindy W. Leung   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Prenatal and Perinatal Factors of Life’s Essential 8 Cardiovascular Health Trajectories

JAMA Network Open
ImportanceThe American Heart Association put forth the Life’s Essential 8 construct to assess cardiovascular health (CVH) based on 8 biological and behavioral factors. Few studies have identified prenatal and perinatal factors of CVH trajectories across childhood and adolescence, life stages where disease precursors and health behaviors are established.
Aris, Izzuddin M., Rifas-Shiman, Sheryl L., de Ferranti, Sarah D., Hivert, Marie-France, Perng, Wei   +4 more
openaire   +2 more sources