Results 121 to 130 of about 10,008,519 (256)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Assessing the impact of volatile organic compounds on cardiovascular health: Insights from the National Health and Nutrition Examination Survey 2011–2020

Ecotoxicology and Environmental Safety
Volatile organic compounds (VOCs) are environmental pollutants that may negatively impact cardiovascular health. This study investigates the association between VOC mixtures, measured through urinary VOC metabolites (VOCMs), and cardiovascular health ...
Lina Wang, Jianqiang Du, Xiaoming Wu, Zhenhai Gan   +3 more
doaj   +1 more source

Cardiovascular health of the Krasnoyarsk Krai population according to the adapted Life's Essential 8 score

Aim . To assess the level of cardiovascular health (CVH) in a representative sample of the Krasnoyarsk Krai population using the adapted Life's Essential 8 (LE8) score.
Yu. I. Grinshtein, Yu. A. Balanova, S. A. Shalnova, R. R. Ruf, V. V. Shabalin, O. M. Drapkina   +5 more
core   +1 more source

TEHIP news, issue no. 8, December 2003 : closing the loop

, 2003
"A newsletter of the IDRC/MOH Tanzania Essential Health Interventions Project ...
Tanzania Essential Health Interventions Project
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Association between Life's Essential 8 and hyperuricemia in the Chinese elderly.

Asia Pacific journal of clinical nutrition
Life's Essential 8 (LE8) is a comprehensive indicator that evaluates cardiovascular health (CVH). There have been limited studies on the relationship between LE8 and hyperuricemia (HUA). This study explored the association and dose-response relationship between LE8 and HUA among elderly people in China.The subjects were the elderly aged 60 and over who
Jiao, Yingying, Wang, Liusen, Hong, Xi, Li, Weiyi, Jiang, Hongru, Jia, Xiaofang, Wang, Huijun, Zhang, Bing, Wang, Zhihong, Ding, Gangqiang   +9 more
openaire   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Epigenetic Age Mediates the Association of Life's Essential 8 With Cardiovascular Disease and Mortality

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Life's Essential 8 (LE8) is an enhanced metric for cardiovascular health. The interrelations among LE8, biomarkers of aging, and disease risks are unclear.
Madeleine Carbonneau, Yi Li, Brenton Prescott, Chunyu Liu, Tianxiao Huan, Roby Joehanes, Joanne M. Murabito, Nancy L. Heard‐Costa, Vanessa Xanthakis, Daniel Levy, Jiantao Ma   +10 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source