Results 101 to 110 of about 10,008,519 (256)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Association of Life's Crucial 9 score with advanced cardiovascular-kidney-metabolic syndrome in U.S. adults

European Journal of Medical Research
Background Cardiovascular-kidney-metabolic (CKM) syndrome, a progressively advancing disorder involving metabolic, renal, and cardiovascular dysfunction, was newly defined by the American Heart Association in its latest recommendations. Life's Crucial 9 (
Xingyang Zhao, Sujia Hu, Weilin Liu, Shuwang Ge, Gang Xu   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Life's Essential 8 and Life's Simple 7 in relation to coronary atherosclerosis : results from the population-based scapis project

Objective: To examine the associations between the American Heart Association scores ("Life's Essential 8" [LE8] and "Life's Simple 7" [LS7]) and 2 subclinical coronary atherosclerosis indicators: coronary computed tomographic angiography (CCTA)-stenosis
Berglind, Daniel, Ortega, Francisco B., Ahlqvist, Viktor H.,, Daka, B, Higueras Fresnillo, Sara, Lenander, Cecilia, Ortega, Francisco B.,, Rådholm, Karin,, Herraiz-Adillo, Ángel, Rådholm, Karin, Syrjälä, Maria B., Syrjälä, Maria B.,, Higueras-Fresnillo, S, Ortega, FB, Daka, Bledar, Östgren, Carl Johan, Berglind, Daniel,, Lenander, Cecilia,, Henriksson, Pontus,, Berglind, D,, Sundström, Johan,, Brännholm Syrjälä, Maria,, Ostgren, C-J, Herraiz-Adillo, A, Syrjala, MB, Östgren, Carl-Johan, Sundstrom, J, Ahlqvist, VH, Ahlqvist, Viktor H., Higueras-Fresnillo, Sara,, Higueras-Fresnillo, Sara, Sundström, Johan, Lenander, C, Östgren, Carl Johan,, Östgren, Carl-Johan,, Henriksson, Pontus, Lund University., Brännholm Syrjälä, Maria, Herraiz-Adillo, Ángel,, Daka, Bledar,   +39 more
core   +1 more source

Association of neighborhood-level socioeconomic disadvantage and Life's Essential 8 in early pregnancy [PDF]

We examined whether neighborhood-level socioeconomic disadvantage per the Area Deprivation Index (ADI) was associated with maternal cardiovascular health (CVH) in early pregnancy per the American Heart Association Life's Essential 8 (LE8).
George Saade, Khan, Sadiya, Reddy, Uma, Philip Greenland, Simhan, Hy, David M. Haas, Mercer, Brian, Levine, Lisa, Chung, Judith, Greenland, Philip, Janet Catov, Hy Simhan, Lisa D. Levine, Huang, Xiaoning, Xiaoning Huang, Judith Chung, Robert M. Silver, Haas, David, Lynn M. Yee, Catov, Janet, Sadiya S Khan, Yee, Lynn, Silver, Robert, Uma Reddy, Venkatesh, Kartik, Saade, George, C. Noel Bairey Merz, William A. Grobman, Brian Mercer, Becky McNeil, McNeil, Becky, Kartik K. Venkatesh, Bairey Merz, C, Grobman, William   +33 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Association of life’s essential 8 with mortality among the individuals with cardiovascular disease

Scientific Reports
This study explores the association between LE8 scores and mortality risks among individuals diagnosed with cardiovascular disease (CVD). Utilizing data from the NHANES conducted between 2005 and 2018, survey-weighted multivariable Cox proportional hazards regression models were utilized.
Ying Yang, Ye Wang, Yanping Mao, Feiyun Zhu, Man Zhang, Mengshan Pan, Tongle Yin, Jiamin Xu, Rucheng Chen, Weijun Zheng   +9 more
openaire   +3 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source