Results 121 to 130 of about 4,058,838 (360)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Effects of age and physical activity on the autonomic control of heart rate in healthy men

open access: yesBrazilian Journal of Medical and Biological Research, 2005
The effects of the aging process and an active life-style on the autonomic control of heart rate (HR) were investigated in nine young sedentary (YS, 23 ± 2.4 years), 16 young active (YA, 22 ± 2.1 years), 8 older sedentary (OS, 63 ± 2.4 years) and 8 older
R.C. Melo   +10 more
doaj   +1 more source

National Blueprint: Increasing Physical Activity Among Adults Age 50 and Older [PDF]

open access: yes, 2001
Outlines a variety of approaches for organizations, associations, and agencies to plan strategies to help people age 50 and older increase their physical ...

core  

Myocardial aging as a T-cell–mediated phenomenon [PDF]

open access: yes, 2017
In recent years, the myocardium has been rediscovered under the lenses of immunology, and lymphocytes have been implicated in the pathogenesis of cardiomyopathies with different etiologies.
Abeßer, Marco   +15 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Effect of Healthy Lifestyle Educational Programs on Happiness and Life Satisfaction in the Elderly: A Randomized Controlled Trial Study

open access: yesSālmand, 2019
Objectives Like the global population, the Iranian population is aging rapidly. Measures should be taken to maintain aging population healthy and happy.
Mohammad Mohammadi Mehr   +3 more
doaj  

Evaluation of the concept of pressure proof testing fuselage structures [PDF]

open access: yes
The FAA and NASA have recently completed independent technical evaluations of the concept of pressure proof testing the fuselage of commercial transport airplanes. The results of these evaluations are summarized. The objectives of the evaluations were to
Harris, Charles E., Orringer, Oscar
core   +1 more source

Identifying prognostic indicators for electrical treeing in solid insulation through pulse sequence analysis [PDF]

open access: yes, 2014
Predictive maintenance attempts to evaluate the condition of equipment and predict the future trend of the equipment's aging, in order to reduce costs when compared to the two traditional approaches: corrective and preventive maintenance. This prediction
Aziz, Nur Hakimah   +2 more
core  

Gender and sexual orientation differences in cognition across adulthood : age is kinder to women than to men regardless of sexual orientation [PDF]

open access: yes, 2007
Despite some evidence of greater age-related deterioration of the brain in males than in females, gender differences in rates of cognitive aging have proved inconsistent.
A. E. Grulich   +84 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

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