Results 91 to 100 of about 9,912,419 (304)

Demographic perspectives on the transition to adulthood: An introduction

, 2010
This special issue of Advances in Life Course Research is dedicated to a demographic perspective on the transition to adulthood. In our view, there are at least two compelling reasons to do so.
Toulemon, L., Laurent Toulemon, Aart C. Liefbroer, Liefbroer, A.C.; id_orcid, Liefbroer, A.C.   +4 more
core   +1 more source

Cognitive capital: the case for a construct [PDF]

, 2010
Cognitive functioning and its outcomes in educational performance and improved life chances  tends to rely on a model of human functioning derived from 19th century thinking about intelligence resting on fixed abilities.
Bynner, John, Wadsworth, Michael
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Temporal trends in pregnancy outcomes during a health system shock

Communications Medicine
Background To better understand reported COVID-19 pandemic effects on pregnancy, we examined temporal trends in pregnancy outcomes in a diverse population from South London, United Kingdom.
Florence Tydeman, Kathryn V. Dalrymple, Alice McGreevy, Lucilla Poston, Tisha Dasgupta, Abigail Easter, Asma Khalil, Lisa Long, Hiten D. Mistry, Daghni Rajasingam, Sergio A. Silverio, Marina Soley-Bori, Yanzhong Wang, Sara L. White, The RESILIENT Study Group, The Early Life Cross Linkage in Research, Born in South London (eLIXIR-BiSL) Partnership, Peter von Dadelszen, Laura A. Magee   +17 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Idiopathic Distal Sensory Polyneuropathy and Fibromyalgia Syndrome: A Comparative Phenotyping Study

Pain and Therapy
Introduction Painful idiopathic distal sensory polyneuropathy (IDSP) and fibromyalgia syndrome (FMS) are cryptogenic chronic pain syndromes. The contribution of small fibre pathology (SFP) in FMS remains controversial.
Jamie Burgess, Anne Marshall, Leandros Rapteas, David Riley, Kohei Matsumoto, Cheng Boon, Alia Alchawaf, Maryam Ferdousi, Rayaz A. Malik, Andrew Marshall, Stephen Kaye, David Gosal, Bernhard Frank, Uazman Alam   +13 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The Preterm Clinical Network (PCN) Database: a web-based systematic method of collecting data on the care of women at risk of preterm birth

BMC Pregnancy and Childbirth, 2018
Background Despite much research effort, there is a paucity of conclusive evidence in the field of preterm birth prediction and prevention. The methods of monitoring and prevention strategies offered to women at risk vary considerably around the UK and ...
Jenny Carter, Rachel M. Tribe, Jane Sandall, Andrew H. Shennan, the UK Preterm Clinical Network   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Mobile phone apps for clinical decision support in pregnancy: a scoping review

BMC Medical Informatics and Decision Making, 2019
Background The use of digital technology in healthcare has been found to be useful for data collection, provision of health information and communications.
Jenny Carter, Jane Sandall, Andrew H. Shennan, Rachel M. Tribe   +3 more
doaj   +1 more source