Results 101 to 110 of about 5,892,346 (305)

Longitudinal cross-lagged analysis of depression, loneliness, and quality of life in 12 European countries

BMC Public Health
Background In the older population, depression, loneliness, and quality of life are closely related, significantly influencing health status. This paper aimed (1) to investigate autoregressive and cross-lagged associations over 2 years between depression,
Marcelo de Maio Nascimento, Charikleia Lampraki, Adilson Marques, Élvio R. Gouveia, Jose C. Adsuar, Andreas Ihle   +5 more
doaj   +1 more source

Recall error and recall bias in life course epidemiology [PDF]

OBJECTIVES I propose a distinction between recall error and recall bias and examine the the effect of childhood financial hardship on adult health, subject to such recall problems.
Tampubolon, Gindo
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Evaluating acceptability and experiences of pregnant women at high risk of developing gestational diabetes who take part in antenatal intervention trials: a qualitative systematic review

BMC Pregnancy and Childbirth
Background Gestational diabetes mellitus (GDM) is associated with short- and longer-term adverse outcomes for both mother and child. The success of randomised controlled trials (RCTs) assessing interventions to prevent GDM depends in part on participant ...
Gözde Sultan Çakır, Manar Abduljalil Bakhsh, Ola F. Quotah, Olivia Righton, Catherine V. George, Lucilla Poston, Sara L. White, Angela C. Flynn, Zoë Bell   +8 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The Problem Based Learning (PBL)-Based Entrepreneurship Learning Model Development to Improve the Life Skills of the Teacher Training Students in Private Universities throughout Solo Raya [PDF]

, 2012
Purpose – This research aims at providing a PBL-based Entrepreneurship learning model to improve the student life skills in Private Faculties of Teacher Training and Educationin Solo Raya.
Suryanti, Hera Heru Sri
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

ABOVE: cerclage after caesarean: protocol for a randomised controlled trial to assess the optimal preventative management for preterm birth secondary to caesarean section damage

BMC Pregnancy and Childbirth
Background There is emerging evidence that caesarean section in labour is associated with an increased risk of recurrent mid-trimester loss (MTL) and spontaneous preterm birth (sPTB) in subsequent pregnancies.
Laura van der Krogt, Jenny Carter, Giorgia Dalla Valle, Natalie Suff, Lisa Story, Rachel M. Tribe, Andrew Shennan   +6 more
doaj   +1 more source

Early childhood and the life course [PDF]

What happens to children in the early years has consequences right through the course of their lives. There are many opportunities to intervene and make a difference to the lives of children and young people.
Centre for Community Child Health
core