Results 101 to 110 of about 9,912,419 (304)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Methodologies for establishing and validating cut-points and comparative standards in medical imaging-based body composition analysis: a scoping review protocol

Systematic Reviews
Background Medical imaging-based body composition analysis (BCA) has shown promise in offering detailed, noninvasive assessments of fat, muscle, and bone, but challenges persist in establishing consistent comparative standards.
Alanood Aljanahi, Kathryn V. Dalrymple, Eirini Dimidi, Erin Stella Sullivan   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Longitudinal cross-lagged analysis of depression, loneliness, and quality of life in 12 European countries

BMC Public Health
Background In the older population, depression, loneliness, and quality of life are closely related, significantly influencing health status. This paper aimed (1) to investigate autoregressive and cross-lagged associations over 2 years between depression,
Marcelo de Maio Nascimento, Charikleia Lampraki, Adilson Marques, Élvio R. Gouveia, Jose C. Adsuar, Andreas Ihle   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Evaluating acceptability and experiences of pregnant women at high risk of developing gestational diabetes who take part in antenatal intervention trials: a qualitative systematic review

BMC Pregnancy and Childbirth
Background Gestational diabetes mellitus (GDM) is associated with short- and longer-term adverse outcomes for both mother and child. The success of randomised controlled trials (RCTs) assessing interventions to prevent GDM depends in part on participant ...
Gözde Sultan Çakır, Manar Abduljalil Bakhsh, Ola F. Quotah, Olivia Righton, Catherine V. George, Lucilla Poston, Sara L. White, Angela C. Flynn, Zoë Bell   +8 more
doaj   +1 more source

Negotiating the Life Course, 2003, Wave 3

, 2019
Negotiating the Life Course is designed to study the changing life courses and decision-making processes of Australian men and women as the family and society move from male breadwinner orientation in the direction of higher levels of gender equity.
Gray, Edith, Breusch, Trevor, Mitchell, Deborah A., McDonald, Peter, Evans, Ann, Baxter, Janeen   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Negotiating the Life Course, 2006, Wave 4

, 2019
Negotiating the Life Course is designed to study the changing life courses and decision-making processes of Australian men and women as the family and society move from male breadwinner orientation, in the direction of higher levels of gender equity ...
Gray, Edith, Mitchell, Deborah A., McDonald, Peter, Evans, Ann, Baxter, Janeen, Baxter, Jennifer   +5 more
core   +1 more source