Results 121 to 130 of about 9,912,419 (304)

Volume 9, No 2

, 2018
Full issue of Longitudinal and Life Course Studies journal, Volume 9, No ...
Jeal, Sarah
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Life Course [PDF]

, 2021
Johannes Huinink, Betina Hollstein
openaire   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Developmental and Life-Course Findings on Women and Girls

, 2018
This chapter builds on theoretical insights from the gendered pathways literature to interpret the evidence regarding the influence of gender on life-course offending patterns.
Thompson, CM, Thompson, Carleen, Broidy, Lisa, Broidy, LM   +3 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Higher adherence to (poly)phenol-rich diet is associated with lower CVD risk in the TwinsUK cohort

BMC Medicine
Background Previous studies have reported inverse associations between total (poly)phenol intake or specific subclasses of (poly)phenols, estimated from dietary questionnaires, and cardiovascular disease (CVD) risk.
Yong Li, Xinyu Yan, Yifan Xu, Robert Pope, Tim D Spector, Mario Falchi, Claire J Steves, Jordana T Bell, Kerrin S Small, Cristina Menni, Rachel Gibson, Ana Rodriguez-Mateos   +11 more
doaj   +1 more source

Effects of Parental Cultural and Economic Status on Adolescents’ Life Course Preferences

, 2016
This article examines to what extent adolescents’ ideas about their future life course in the professional and family domain are influenced by the cultural and economic status of their parents, and to what extent these influences are mediated by parents’
Keijer, M.G., Nagel, Ineke, Nagel, I., Nagel, I.; id_orcid, Keijer, Micha G., Liefbroer, A.C.; id_orcid, Liefbroer, Aart C., Liefbroer, A.C.   +7 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A Life Course Perspective on Chinese Youths [PDF]

This open access book investigates from a life-course perspective the individualization process and the challenges faced by young adults in post-collectivist China, where people are enjoined to "liberate" (jiefang) their individual capacities, to "rely ...
Constantin, Sandra V.
core   +1 more source