Results 111 to 120 of about 5,892,346 (305)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Evidence for spinal disinhibition as a pain-generating mechanism in fibromyalgia syndrome

PAIN Reports
. Introduction:. Pain phenomenology in patients with fibromyalgia syndrome (FMS) shows considerable overlap with neuropathic pain. Altered neural processing leading to symptoms of neuropathic pain can occur at the level of the spinal cord, and 1 ...
Anne Marshall, Jamie Burgess, Andreas Goebel, Bernhard Frank, Uazman Alam, Andrew Marshall   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Health workforce strategies during COVID-19 response: insights from 15 countries in the WHO Africa Region

BMC Health Services Research
Introduction The COVID-19 pandemic unveiled huge challenges in health workforce governance in the context of public health emergencies in Africa. Several countries applied several measures to ensure access to qualified and skilled health workers to ...
Adam Ahmat, Sunny C Okoroafor, James Avoka Asamani, Millogo Jean, Abdou Illou Mourtala, Jennifer Nyoni, Kasonde Mwinga   +6 more
doaj   +1 more source

Early-life neighborhood context, perceived stress, and preterm birth in African American Women. [PDF]

, 2019
Stressors from multiple sources, across the life-course, may have independent and joint associations with preterm birth (PTB) risk in African American women. Using data from the Life-course Influences on Fetal Environments Study (LIFE; 2009-2011) of post-
Misra, Dawn P, Mustafaa, Faheemah N, Sealy-Jefferson, Shawnita   +2 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Small fibre pathology, small fibre symptoms and pain in fibromyalgia syndrome

Scientific Reports
A proportion of people with fibromyalgia demonstrate small fibre pathology (SFP). However, it is unclear how SFP directly relates to pain phenomenology. Thirty-three individuals with FMS and ten healthy volunteers underwent assessment of SFP and sensory ...
Anne Marshall, Leandros Rapteas, Jamie Burgess, David Riley, Matthew Anson, Kohei Matsumoto, Amanda Bennett, Stephen Kaye, Andrew Marshall, James Dunham, Nicholas Fallon, Sizheng S. Zhao, Anne Pritchard, Nicola Goodson, Rayaz A. Malik, Andreas Goebel, Bernhard Frank, Uazman Alam   +17 more
doaj   +1 more source

Sex Differences in Stroke Care and Outcomes: A National Stroke Registry Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous evidence on sex differences in stroke care and outcomes was limited in sample representativeness and coverage of care indicators. We aim to investigate various indicators of stroke care quality, survival, and functional outcome at ...
Min Xu, Youssef Hbid, Kaili Stanley, Charles Wolfe, Matthew D. L. O'Connell, Abdel Douiri   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Lockdown in Manchester is a Slippery Slope [PDF]

, 2016
[Excerpt] Liberty. Security. Both are essential to a good life. But of course, neither is absolute, and at times circumstances demand that a society trade some measure of liberty for security.
Evans, Risa
core   +1 more source