Results 31 to 40 of about 5,892,346 (305)

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Long‐Term Risk of Stroke Recurrence: A  Competing Risk Analysis Based on the South London Stroke Register

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies on stroke recurrence often ignored the competing risk of death, potentially biasing risk estimates. This study estimated stroke recurrence risk and identified associated factors among patients with first‐ever stroke in South ...
Li Zhang, Marc Delord, Iain Marshall, Charles Wolfe, Yanzhong Wang, Matthew D. L. O’Connell   +5 more
doaj   +1 more source

Sustainable Work Over the Life Course: Concept Paper [PDF]

, 2015
Ageing of the population is likely to threaten the ability of states to finance welfare states and social protection systems in the future. A viable solution is to increase employment rates and to lengthen working life. To achieve this dual goal requires
Eurofound
core   +1 more source

A modern course on digital design at the University of Twente [PDF]

, 1992
At the University of Twente, the Netherlands a modern course on basic digital design has been developed. This course, which is based on a text book in English (K. J.
Beusekamp, M.F.
core   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Benchmarking survival machine learning models for 10-year cardiovascular disease risk prediction using large-scale electronic health records

Digital Health
Objective To evaluate the performance of machine learning (ML)-based survival models for 10-year cardiovascular disease (CVD) risk prediction using large-scale electronic health records (EHRs).
Tianyi Liu, Andrew Krentz, Lei Lu, Yanzhong Wang, Vasa Curcin   +4 more
doaj   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Mode of infant feeding, eating behaviour and anthropometry in infants at 6-months of age born to obese women – a secondary analysis of the UPBEAT trial

BMC Pregnancy and Childbirth, 2018
Background Maternal obesity and rapid infant weight gain have been associated with increased risk of obesity in childhood. Breastfeeding is suggested to be protective against childhood obesity, but no previous study has addressed the potential benefit of
Nashita Patel, Kathryn V. Dalrymple, Annette L. Briley, Dharmintra Pasupathy, Paul T. Seed, Angela C. Flynn, Lucilla Poston, on behalf of the UPBEAT Consortium   +7 more
doaj   +1 more source

Systematic review and narrative synthesis of suicide prevention in high-schools and universities: a research agenda for evidence-based practice

BMC Public Health, 2021
Background Youth suicide prevention in high-schools and universities is a public health priority. Our aim was to propose a research agenda to advance evidence-based suicide prevention in high-schools and universities by synthesizing and critically ...
Elsie Breet, Matsie Matooane, Mark Tomlinson, Jason Bantjes   +3 more
doaj   +1 more source