Results 71 to 80 of about 14,412,106 (353)

Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation

Bone Research
Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor whose dysfunction is linked to developmental dysplasia of the hip, osteoporosis and osteoarthritis.
Mohammad Alhashmi, Abdulrahman M. E. Gremida, Santosh K. Maharana, Marco Antonaci, Amy Kerr, Shijian Fu, Sharna Lunn, David A. Turner, Noor A. Al-Maslamani, Ke Liu, Maria M. Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N. Wheeler, Robert J. van ‘t Hof, George Bou-Gharios, Kazuhiro Yamamoto   +17 more
doaj   +1 more source

Does closed-loop automated oxygen control reduce the duration of supplementary oxygen treatment and the amount of time spent in hyperoxia? A randomised controlled trial in ventilated infants born at or near term

Trials, 2023
Background Ventilated infants frequently require supplemental oxygen, but its use should be monitored carefully due to associated complications. The achievement of oxygen saturation (SpO2) targets can be challenging as neonates experience frequent ...
Ourania Kaltsogianni, Theodore Dassios, Allan Jenkinson, Anne Greenough   +3 more
doaj   +1 more source

Coping with a changing world: the UK Open University approach to teaching ICT [PDF]

, 2008
The rapid pace of change in the ICT field has affected all HE providers, but for the UK Open University (UKOU), used to print-based courses lasting eight years or more, it has been a particular challenge. This paper will present some of the ways the UKOU
Bissell, C C, Williams, J P
core   +1 more source

US open access life cycle [PDF]

, 2015
Based on the UK open access life cycle, in the centre circle, we have used the 7 stages of the publishing process as described by Neil Jacobs (Jisc), this is followed by institutional processes – of course not all institutions will have all of these ...
Emery, Jill, Stone, Graham
core   +1 more source

Holistic analysis of the life course: Methodological challenges and new perspectives.

Advances in Life Course Research, 2019
We survey state-of-the-art approaches to study trajectories in their entirety, adopting a holistic perspective, and discuss their strengths and weaknesses.
R. Piccarreta, M. Studer
semanticscholar   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Noise and sound in the intensive care unit: a cohort study

Scientific Reports
Intensive care units (ICUs) are acknowledged for their propensity for noise, often exhibiting higher sound levels on average than other departments.
A. Tahvili, A. Waite, T. Hampton, I. Welters, P. J. Lee   +4 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interventions in preconception and pregnant women at risk of gestational diabetes; a systematic review and meta-analysis of randomised controlled trials

Diabetology & Metabolic Syndrome
Background Women at risk of gestational diabetes mellitus (GDM) need preventative interventions. Objective To evaluate targeted interventions before and during pregnancy for women identified as being at risk of developing GDM.
Ola F. Quotah, Daria Andreeva, Katarzyna G. Nowak, Kathryn V. Dalrymple, Aljawharah Almubarak, Anjali Patel, Nirali Vyas, Gözde S. Cakir, Nicola Heslehurst, Zoe Bell, Lucilla Poston, Sara L. White, Angela C. Flynn   +12 more
doaj   +1 more source

Developing an online course to support student transitions to university [PDF]

, 2017
The University of Strathclyde developed "We are Strathclyde", an online course developed to aid the transition of incoming undergraduate students into university life.
Johnston, Aidan, Ramsay, Howard
core