Results 171 to 180 of about 4,110,851 (310)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Synergistic Effects of Lignocellulosic Baglog Compost and Biochar on Tomato Plant Growth

BioResources
Indonesian agriculture faces multifaceted challenges, particularly the need to enhance productivity while maintaining environmental sustainability to ensure high-quality food production.
Titin Handayani, Septi Syahrani, Ira Nurhayati Djarot, Agusta Samodra Putra, Netty Widyastuti, Akhmad Rifai, Amita Indah Sitomurni, Diana Nurani, Djatmiko Pinardi, Noorwitri Utami, Nuha Nuha, Sri Peni Wijayanti, Ari Kabul Paminto, Anisa Lutfia, Afifah Nurmala Karima, Hanifah Nisrina, Azalea Eugenie, Rizki Amaliyah, Arief Barkah   +18 more
doaj  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Life Cycle Assessment and Life Cycle Costing of Supercapacitors: A Comprehensive Review and Assessment of Environmental and Economic Impacts. [PDF]

ChemSusChem
Bahmei F, de Buruaga AS, Bautista SP, Olarte J, Ajuria J, Varzi A, Weil M.   +6 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A sweet corn metabolic regulatory network spanning the entire life cycle. [PDF]

Mol Hortic
Ma L, Zuo J, Fernie AR, Liu S, Zhou X, Jing Z, Wang Y, Feng X, Ren Y, Wu C, Wang R, Shi Y, Zheng Y.   +12 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Hypertension in Women Across the Life Cycle: Unique Aspects and Challenges. [PDF]

Curr Hypertens Rep
Bond RM, Purewal V, Cameron N, Tobb K, Adedinsewo D, Isiadinso I, Phillips K.   +6 more
europepmc   +1 more source