Results 181 to 190 of about 1,623,376 (313)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Life Cycle Assessment of Biodeisel Production From Moringa Oleifera Oilseeds

, 2009
Biswas, Wahidul, Rosano, Michele
core  

Ubiquitin ligase ITCH regulates life cycle of SARS-CoV-2 virus. [PDF]

Elife
Xiang Q, Wouters C, Chang P, Lu YN, Liu M, Wang H, Heine H, Qian S, Yang J, Pekosz A, Zhang Y, Wang J.   +11 more
europepmc   +1 more source

Synergistic Effects of Lignocellulosic Baglog Compost and Biochar on Tomato Plant Growth

BioResources
Indonesian agriculture faces multifaceted challenges, particularly the need to enhance productivity while maintaining environmental sustainability to ensure high-quality food production.
Titin Handayani, Septi Syahrani, Ira Nurhayati Djarot, Agusta Samodra Putra, Netty Widyastuti, Akhmad Rifai, Amita Indah Sitomurni, Diana Nurani, Djatmiko Pinardi, Noorwitri Utami, Nuha Nuha, Sri Peni Wijayanti, Ari Kabul Paminto, Anisa Lutfia, Afifah Nurmala Karima, Hanifah Nisrina, Azalea Eugenie, Rizki Amaliyah, Arief Barkah   +18 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Spatiotemporal Analysis of the Carbon Footprint of Soybean Production in China Based on Life Cycle Assessment. [PDF]

Foods
Ning G, Yang F, Zhao J, Wang S.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Reviewing a Theory Life Cycle in Disaster Management. [PDF]

Risk Anal
Ha KM.
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Parametric Life Cycle Assessment of Chemical Recycling of Nylon-6 to Caprolactam. [PDF]

Environ Sci Technol
Minor AJ, Goldhahn R, Ganzer C, Lejeune M, Rihko-Struckmann L, Sundmacher K.   +5 more
europepmc   +1 more source