Results 61 to 70 of about 1,232,833 (305)

Research on Highway Maintenance and Management Cost Based on Life Cycle Cost Analysis [PDF]

open access: yesE3S Web of Conferences
With the rapid development of China’s highway construction, the huge demand for funds and the lack of financial strength of the contradiction is increasingly obvious, can effectively control the maintenance costs, highway operators to obtain sustainable ...
Li Jiarong, Gou Lijuan, Men Feng
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Life cycle management of natural infrastructure: assessment of state of practice and current tools

open access: yesFrontiers in Built Environment
Design alternatives for traditional infrastructure are often compared in terms of expected–and often narrowly defined–costs and benefits to justify the selected plan.
Margaret H. Kurth   +4 more
doaj   +1 more source

A multi-objective framework for the optimisation of life-cycle costs of wind turbines [PDF]

open access: yes, 2016
Peer reviewedPublisher ...
Hanish Nithin, Anu, Omenzetter, Piotr
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

A normative price for energy from an electricity generation system: An Owner-dependent Methodology for Energy Generation (system) Assessment (OMEGA). Volume 2: Derivation of system energy price equations [PDF]

open access: yes
The methodology presented is a derivation of the utility owned solar electric systems model. The net present value of the system is determined by consideration of all financial benefits and costs including a specified return on investment.
Chamberlain, R. G., Mcmaster, K. M.
core   +1 more source

Safety Engineering with COTS components [PDF]

open access: yes, 2017
Safety-critical systems are becoming more widespread, complex and reliant on software. Increasingly they are engineered through Commercial Off The Shelf (COTS) (Commercial Off The Shelf) components to alleviate the spiralling costs and development time ...
Caseley   +11 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

LIFE-CYCLE COST AS AN ASSESSMENT OF THE FINANCIAL EFFECTIVENESS OF AN INVESTMENT AND CONSTRUCTION PROJECT OF SOCIAL INFRASTRUCTURE

open access: yesВестник университета, 2020
Original approach to assessment and evaluation of financial effectiveness of an investment project in state area via the life-cycle cost has been proposed.
A. A. Kuznetsov
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

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