Results 121 to 130 of about 174,427 (313)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Gamma modeling of continuous deterioration and cumulative damage in life-cycle analysis of earthquake-resistant structures

, 2013
Stochastic modeling of structural deterioration at the scale of the life - cycle is the subje ct of the study . The categories of degradation phenomena considered are those two typical of structures, that is , co n- tinuous degradation of mechanical ...
IERVOLINO, IUNIO, Chioccarelli E, M. Giorgio, Iervolino I, CHIOCCARELLI, EUGENIO, Eugenio Chioccarelli, Massimiliano Giorgio, Iunio Iervolino, GIORGIO, Massimiliano   +8 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A Feature-Based Application based on KBE Technology: an Automatic Configuration System for Hydraulic Cylinders

, 2001
Proceedings of the IFIP - FEATS 2001, International Conference on Feature Modeling and Advanced Design-For-The-Life-Cycle ...
S. BERTI, GERMANI, Michele, MANDORLI, Ferruccio   +2 more
core  

Managing User Capabilities in Information Systems Life Cycle: Conceptual Modeling

International Journal of Information Science and Management, 2016
Information Systems (IS) acquisition prescribes induction of information technologies (IT) in the organization. At times, IS is used for managing broader enterprise level issues like implementing e-business, e-commerce.
Harekrishna Misra
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Operation Modeling Within the Framework of Life Test Optimization for Gas Turbine Engine Based on Life Cycle Model

Energies
The choice of parameters for the life tests of gas turbine engines is a complex multi-criteria task. In this article, as a tool for solving this task, it is proposed to use simulation modeling of the engine life cycle to select gas turbine engine life ...
Natalya Kondratyeva, Sagit Valeev
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Petri Net Modeling of Computer Virus Life Cycle

, 2012
Virus life cycle, which refers to the stages of development of a computer virus, is presented as a suitable area for the application of Petri nets. Petri nets a powerful modeling tool in the field of dynamic system analysis is applied to model the virus ...
Ikekonwu, GA, Bakpo, FS
core   +1 more source