Results 121 to 130 of about 908,324 (360)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Managing User Capabilities in Information Systems Life Cycle: Conceptual Modeling
International Journal of Information Science and Management, 2016 Information Systems (IS) acquisition prescribes induction of information technologies (IT) in the organization. At times, IS is used for managing broader enterprise level issues like implementing e-business, e-commerce.
Harekrishna Misra
doaj
EnergiesThe choice of parameters for the life tests of gas turbine engines is a complex multi-criteria task. In this article, as a tool for solving this task, it is proposed to use simulation modeling of the engine life cycle to select gas turbine engine life ...
Natalya Kondratyeva, Sagit Valeev
doaj +1 more source
Financial Risk, Retirement, Saving and Investment [PDF]
This paper considers the prospects for adding choice of portfolio composition to a life cycle model of retirement and saving, while preserving the ability of the model to continue to explain the course of saving and retirement.
Alan Gustman, Thomas Steinmeier
core
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Decision-making for UBC High Performance Buildings: Multi-criteria Analysis for Integrated Life Cycle Models [PDF]
, 2010 The current paradigm of building design is evolving rapidly and building developers are beginning to dopt sustainable building practices across Canada.
Storey, S.
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Household Responses to Individual Shocks: Disability and Labor Supply [PDF]
What are idiosyncratic shocks and how do people respond to them? This paper starts from the observation that idiosyncratic shocks are experienced at the individual level, but responses to shocks can encompass the whole household.
Giovanni Gallipoli, Laura Turner
core
The use of life cycle assessment as an early R&D decision tool: bottlenecks and potential solutions [PDF]
, 2014 At an ever increasing rate innovative chemistry and technology platforms are reshaping manufacturing environments to become factories of the future as being more productive, lean and flexible.
De Meester, Steven +4 more
core +1 more source