Results 101 to 110 of about 908,324 (360)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Spatial- and Time-Explicit Human Damage Modeling of Ozone Depleting Substances in Life Cycle Impact Assessment [PDF]
, 2009 Jaap Struijś +6 more
openalex +1 more source
Operations and support cost modeling using Markov chains [PDF]
Systems for future missions will be selected with life cycle costs (LCC) as a primary evaluation criterion. This reflects the current realization that only systems which are considered affordable will be built in the future due to the national budget ...
Unal, Resit
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Holistic energy system modeling combining multi-objective optimization and life cycle assessment
Environmental Research Letters, 2017 Making the global energy system more sustainable has emerged as a major societal concern and policy objective. This transition comes with various challenges and opportunities for a sustainable evolution affecting most of the UN’s Sustainable Development ...
Sebastian Rauner, Maik Budzinski
doaj +1 more source
Transpiration during life cycle in controlled wheat growth [PDF]
A previously developed model of wheat growth, designed for convenient incorporation into system level models of advanced space life support systems is described.
Rummel, John D., Volk, Tyler
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Generating target system specifications from a domain model using CLIPS [PDF]
The quest for reuse in software engineering is still being pursued and researchers are actively investigating the domain modeling approach to software construction.
Gomaa, Hassan +2 more
core +1 more source
Enterprise BIM: A Holistic Approach to the Future of Smart Buildings [PDF]
, 2020 This paper presents Enterprise BIM (EBIM), which is the utilization of Building Information Modeling (BIM) in a holistic organizational aspect structure during the entire life cycle of a building.
Evjen, Tor Åsmund +2 more
core
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source