Results 91 to 100 of about 174,427 (313)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
A statistical distribution useful in product life-cycle modeling [PDF]
Starting from some recent results presented by Isaic â Maniu and Vodă (2008) regarding the Product Life â Cycle (PLC), we propose here an alternative statistical distribution in order to describe all four phases of a product life span.
Emil PETRESCU
core
Management of the LCC considering industrial construction life cycle contracts
MATEC Web of Conferences, 2018 Currently the most urgent problem is increasing the efficiency of industrial construction in the green-field and brown-field formats. Introduction of the development method is a typical organizational form of industrial construction management.
Grabovy Peter, Orlov Alexandr
doaj +1 more source
Авіаційно-космічна техніка та технологія, 2020 The task to optimize the life cycle of new technique (aerospace, engineering products, etc.) in difficult economic conditions is stated and solved. The aim of the study is to develop a method to reduce the life cycle of complex technique creation.
Олег Євгенович Федорович +3 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Commentary: Non-linearity in LCA – What are we talking about?
Frontiers in Sustainability, 2022 Reinout Heijungs +3 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
An application of hybrid life cycle assessment as a decision support framework for green supply chains [PDF]
, 2014 In an effort to achieve sustainable operations, green supply chain management has become an important area for firms to concentrate on due to its inherent involvement with all the processes that provide foundations to successful business.
Lake, A. +14 more
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source