Results 91 to 100 of about 908,324 (360)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The Northern Eurasia Earth Science Partnership: An Example of Science Applied to Societal Needs [PDF]

, 2009
Northern Eurasia, the largest landmass in the northern extratropics, accounts for ~20% of the global land area. However, little is known about how the biogeochemical cycles, energy and water cycles, and human activities specific to this carbon-rich, cold
Aizen, Vladimir B., Cartus, Oliver, Chen, Jiquan, Clark, Elizabeth A., Conard, Susan, Groisman, Pavel Ya., Kattsov, Vladimir M., Katzenberger, John, Krankina, Olga, Kukkonen, Jaakko, Lettenmaier, Dennis P., Machida, Toshinobu, Maksyutov, Shamil, Ojima, Dennis, Qi, Jiaguo, Romanovsky, Vladimir E., Santoro, Maurizio, Schmullius, Christiane C., Shiklomanov, Alexander I., Shimoyama, Kou, Shugart, Herman H., Shuman, Jacquelyn K., Sofiev, Mikhail A., Sokolik, Irina N.   +23 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Modèle FBS-PPR : des objets d'entreprise à la gestion dynamique des connaissances industrielles [PDF]

, 2004
The phases of the life cycle of an industrial product can be described as a network of business processes. Products and informational materials are both raw materials and results of these processes. Modeling using generic model is a solution to integrate
Bernard, Alain, Labrousse, Michel, Perry, Nicolas   +2 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Comparison of Crimean-Congo Hemorrhagic Fever Virus and Aigai Virus in Life Cycle Modeling Systems Reveals a Difference in L Protein Activity. [PDF]

J Virol, 2022
Pickin MJ, Devignot S, Weber F, Groschup MH.   +3 more
europepmc   +1 more source

The functional response of metamorphosis rates to climatic variation: A case study with Amblyomma variegatum [PDF]

, 2012
Amblyomma variegatum is a three host hard tick that has demonstrated extensive range expansion over the last 150 years. This _Tropical Bont Tick_ vectors a number of economically important bacterial diseases of ruminants including the pathogen Ehrlichia ...
Guinat, Claire, Lancelot, Renaud, Pleydell, David, Rahajarison, Patrick, Stachurski, Frédéric   +4 more
core  

Exploring young students creativity: The effect of model eliciting activities [PDF]

, 2014
The aim of this paper is to show how engaging students in real-life mathematical situations can stimulate their mathematical creative thinking. We analyzed the mathematical modeling of two girls, aged 10 and 13 years, as they worked on an authentic task ...
Amit, Miriam, Gilat, Talya
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source