Results 81 to 90 of about 174,427 (313)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Agent-based modeling and life cycle assessment: A systematic review
Cleaner Environmental SystemsLife Cycle Assessment (LCA) is increasingly applied beyond products to assess complex socio-technical systems and support environmental policymaking. However, conventional LCA remains limited by its static representation of processes and by its inability
Paul Carrey +3 more
doaj +1 more source
Modeling of Complex Life Cycle Prediction Based on Cell Division
Journal of Control Science and Engineering, 2017 Effective fault diagnosis and reasonable life expectancy are of great significance and practical engineering value for the safety, reliability, and maintenance cost of equipment and working environment.
Fucheng Zhang, Yahui Wang, De Zhang
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
DATABASE DEVELOPMENT LIFE CYCLE [PDF]
A software development life cycle model (SDLC) consists of a set of processes (planning, requirements, design, development, testing, installation and maintenance) defined to accomplish the task of developing a software application that is functionally ...
Morgan D. Monger +2 more
core
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Some Modeling Challenges in Dynamic Life Cycle Assessment
BioResourcesLife cycle assessment (LCA) has been a mainstream tool to evaluate the environmental impacts of products, services, and systems. Current LCAs inherently rely on the static basis and commonly fail to include temporal considerations.
Kai Lan
doaj +2 more sources