Results 71 to 80 of about 174,427 (313)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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BuildingsThe performance of structures degrades during their service life due to deterioration and extreme events, compromising the social development and economic growth of structure and infrastructure systems.
Ghazanfar Ali Anwar +7 more
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
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Energies, 2020 In this paper, a comprehensive life-cycle assessment (LCA) is carried out in order to evaluate the multiple environmental-health impacts of the biological wastewater treatment of the fish-processing industry throughout its life cycle.
Shinji Takeshita +2 more
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Integrated lifecycle management of engineering products
Технічна інженерія, 2023 This article explores modeling and emulation as pivotal approaches to assist the life cycle stages of a machine-building plant, from design and implementation to operation and existing system optimization.
S.V. , O.S. , D.M.
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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A generic life cycle cost modeling approach for aircraft system
, 2019 Life cycle cost (LCC) is truly representative to the total cost of an aircraft through its life cycle. It is usually used for estimating the cost-effectiveness of an aircraft design. For enabling LCC estimation at early stage, A LCC model have been being
Wang, J +6 more
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Micro-mechanical modelling of high cycle fatigue behaviour of metals under multiaxial loads [PDF]
, 2012 An analysis of high cycle multiaxial fatigue behaviour is conducted through the numerical simulation of polycrystalline aggregates using the finite elementmethod.
PALIN-LUC, Thierry +3 more
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