Results 101 to 110 of about 6,018,721 (240)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Socioeconomic Inequalities in Disability-free Life Expectancy in Older People from England and the United States: A Cross-national Population-Based Study

The journals of gerontology. Series A, Biological sciences and medical sciences, 2020
Background We examined socioeconomic inequalities in disability-free life expectancy in older men and women from England and the United States and explored whether people in England can expect to live longer and healthier lives than those in the United ...
P. Zaninotto, G. D. Batty, S. Stenholm, I. Kawachi, M. Hyde, M. Goldberg, H. Westerlund, J. Vahtera, J. Head   +8 more
semanticscholar   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

Molecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens, Anouk Mentink, Frank A. W. Coumans, Eshwari Dathathri, Khrystany T. Isebia, Jaco Kraan, Ronald de Wit, John W. M. Martens, Leon W. M. M. Terstappen   +8 more
wiley   +1 more source

Direct Healthy Life Expectancy Estimates from Life Tables with a Sullivan Extension. Bridging the Gap Between HALE and Eurostat Estimates [PDF]

arXiv, 2019
The analytic derivation of a more general model of survival-mortality and the estimation of a parameter bx related to the Healthy Life Years Lost (HLYL) is followed with the formulation of a computer program providing results similar to those of the World Health Organization for the Healthy Life Expectancy (HALE) and the corresponding HLYL estimates ...
arxiv  

ICT penetration and life expectancy in emerging market economies: panel evidence from asymmetric causality analysis

BMC Public Health
Background Life expectancy is a significant result indicator of public health and sustainable development. Therefore, one of the final objectives of all economic and social policies is to increase the life expectancy. In this context, a limited number of
Yilmaz Bayar, Ahmet Ozen, Mahmut Unsal Sasmaz, Marina Danilina   +3 more
doaj   +1 more source

One vicinity, two neighbors, and two different stories: a comparison of mortality experiences in Greece and Bulgaria since the 1960s

Journal of Balkan Studies
Greece and Bulgaria are neighboring countries. In the 19th century, the two countries became independent after the Greеk-Turkish and Russian-Turkish Wars, respectively.
Konstantinos Zafeiris, Mariana Mourgova
doaj   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Healthy life gains in South Australia 1999-2008: analysis of a local Burden of Disease series

Population Health Metrics, 2011
Background The analysis describes trends in the levels and social distribution of total life expectancy and healthy life expectancy in South Australia from 1999 to 2008.
Woollacott Tony, Banham David, Lynch John   +2 more
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Resource Abundance and Life Expectancy [PDF]

arXiv, 2017
This paper investigates the impacts of major natural resource discoveries since 1960 on life expectancy in the nations that they were resource poor prior to the discoveries. Previous literature explains the relation between nations wealth and life expectancy, but it has been silent about the impacts of resource discoveries on life expectancy.
arxiv