Results 101 to 110 of about 263,601 (301)

The End of East–West Divergence in European Life Expectancies? An Introduction to the Special Issue [PDF]

, 2017
France Meslé, Jacques Vallin
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design of a prospective, multicentre, observational, comparative study [PDF]

, 2023
Yasuo Okumura, Koichi Nagashima, Ryuta Watanabe, Katsuaki Yokoyama, Takeshi Kato, Hidehira Fukaya, Hidemori Hayashi, Shiro Nakahara, Wataru Shimizu, Yu‐ki Iwasaki, Yuhi Fujimoto, Yasushi Mukai, Koichiro Ejima, Takayuki Otsuka, Shinya Suzuki, Masato Murakami, Masaomi Kimura, Masafumi Harada, Junjiroh Koyama, Hideharu Okamatsu, Teiichi Yamane, Seigo Yamashita, Michifumi Tokuda, Ryohsuke Narui, Mitsuru Takami, Morio Shoda, Tomoo Harada, Ikutaro Nakajima, Katsuhito Fujiu, Kenichi Hiroshima, Kojiro Tanimoto, Tadashi Fujino, Keijiro Nakamura, Koji Kumagai, Ayako Okada, Hideki Kobayashi, Tatsuya Hayashi, Yuji Watari, Mina Hatsuno, Eizo Tachibana, Kazuki Iso, Kazumasa Sonoda, Yoshiyasu Aizawa, Akio Chikata, Satoru Sakagami, Masaru Inoue, Hitoshi Minamiguchi, Nobuhiko Makino, Kazuhiro Satomi, Yoshinao Yazaki, Hideshi Aoyagi, Makoto Ichikawa, Hironori Haruta, Takafumi Hiro, Kimie Okubo, Ken Arima, Taiki Tojo, Hajime Kihara, Satoru Miyanaga, Yoshiaki Fukuda, Koji Oiwa, Tamami Fujiishi, Masashi Akabane, Norikazu Ishikawa, Kengo Kusano, Koji Miyamoto, Haruna Tabuchi, Tomoyuki Shiozawa, Kenjiro Miyamoto, Hiroshi Mase, Kenta Murotani   +70 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Modeling and forecasting healthy life expectancy with Compositional Data Analysis

, 2022
Marie-Pier Bergeron-Boucher, Cosmo Strozza, Violetta Simonacci, Jim Oeppen   +3 more
openalex   +2 more sources

Lifesaving, lifetimes and lifetables

Demographic Research, 2005
Mortality change roils period rates. In the short term, conventional calculations of age-specific probabilities of death and life expectancy in the period immediately after the change depend on how many lives have been saved.
James W. Vaupel
doaj  

Ethnic differences in disability-free life expectancy and disabled life expectancy in older adults in Chile

BMC Geriatrics
Background Although about 10% of the Latin American population is indigenous, ethnic differences in disability-free life expectancy (DFLE) and life expectancy with disability (DLE) are unknown.
Moisés H. Sandoval, Marcela E. Alvear Portaccio, Cecilia Albala   +2 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

DOES EDUCATION AND EMPLOYMENT IMPROVE WOMEN’S LIFE EXPECTANCY IN INDONESIA

, 2021
Muhammad Dzaki Fahd Haekal, Estro Dariatno Sihaloho   +1 more
openalex   +2 more sources