Results 1 to 10 of about 398,606 (255)

Strategies to sensitize cancer cells to immunotherapy

Human Vaccines & Immunotherapeutics, 2021
Recent years have seen the emergence of immunotherapy as a promising modality for treating a variety of cancers. However, the initial data have led to the ultimate reality that such a treatment does not work effectively in all cancers, nor does it ...
Andrew George, Ilyas Sahin, Benedito A. Carneiro, Don S. Dizon, Howard P. Safran, Wafik S. El-Deiry   +5 more
doaj   +1 more source

Prospective associations between working alliance, basic psychological need satisfaction, and coaching outcome indicators: a two-wave survey study among 181 Dutch coaching clients

BMC Psychology, 2022
Background The coach-coachee working alliance and coachee motivation seem important factors for achieving positive coaching results. Self-determination theory, specifically basic psychological need theory, has been proposed as a relevant framework for ...
Margriet Vermeiden, Jennifer Reijnders, Eva van Duin, Marianne Simons, Mayke Janssens, Sanne Peeters, Nele Jacobs, Johan Lataster   +7 more
doaj   +1 more source

Clinical activity of 9-ING-41, a small molecule selective glycogen synthase kinase-3 beta (GSK-3β) inhibitor, in refractory adult T-Cell leukemia/lymphoma

Cancer Biology & Therapy, 2022
GSK-3β is a serine/threonine kinase implicated in tumorigenesis and chemotherapy resistance. GSK-3β blockade downregulates the NF-κB pathway, modulates immune cell PD-1 and tumor cell PD-L1 expression, and increases CD8 + T cell and NK cell function.
Andrew Hsu, Kelsey E. Huntington, Andre De Souza, Lanlan Zhou, Adam J. Olszewski, Nirav P. Makwana, Diana O. Treaba, Ludimila Cavalcante, Francis J. Giles, Howard Safran, Wafik S. El-Deiry, Benedito A. Carneiro   +11 more
doaj   +1 more source

Within-person structures of daily cognitive performance differ from between-person structures of cognitive abilities [PDF]

PeerJ, 2020
Over a century of research on between-person differences has resulted in the consensus that human cognitive abilities are hierarchically organized, with a general factor, termed general intelligence or “g,” uppermost.
Florian Schmiedek, Martin Lövdén, Timo von Oertzen, Ulman Lindenberger   +3 more
doaj   +2 more sources

Cardioprotective effects of early intervention with sacubitril/valsartan on pressure overloaded rat hearts

Scientific Reports, 2021
Left ventricular remodeling due to pressure overload is associated with poor prognosis. Sacubitril/valsartan is the first-in-class Angiotensin Receptor Neprilysin Inhibitor and has been demonstrated to have superior beneficial effects in the settings of ...
Xiaofei Li, Julie Braza, Ulrike Mende, Gaurav Choudhary, Peng Zhang   +4 more
doaj   +1 more source

N‐acetylglutamate synthase deficiency with associated 3‐methylglutaconic aciduria: A case report

JIMD Reports, 2022
N‐acetylglutamate synthase (NAGS) deficiency is a rare autosomal recessive disorder, which results in the inability to activate the key urea cycle enzyme, carbamoylphosphate synthetase 1 (CPS1).
Arthavan Selvanathan, Kalliope Demetriou, Matthew Lynch, Michelle Lipke, Carolyn Bursle, Aoife Elliott, Anita Inwood, Leanne Foyn, Brett McWhinney, David Coman, Jim McGill   +10 more
doaj   +1 more source

Cognitive and hippocampal changes weeks and years after memory training

Scientific Reports, 2022
While immediate effects of memory-training are widely reported in young and older adults, less is known regarding training-dependent hippocampal plasticity across multiple intervention phases, and long-term maintenance of such.
Anne Cecilie Sjøli Bråthen, Øystein Sørensen, Ann-Marie G. de Lange, Athanasia M. Mowinckel, Anders M. Fjell, Kristine B. Walhovd   +5 more
doaj   +1 more source

Geroprotectors and Skeletal Health: Beyond the Headlines

Frontiers in Cell and Developmental Biology, 2022
Osteoporosis and osteoarthritis are the most common age-related diseases of the musculoskeletal system. They are responsible for high level of healthcare use and are often associated with comorbidities.
Alexandra Rayson, Maya Boudiffa, Maneeha Naveed, Jon Griffin, Enrico Dall’Ara, Enrico Dall’Ara, Ilaria Bellantuono   +6 more
doaj   +1 more source

Rates of and factors associated with exclusive and any breastfeeding at six months in Canada: an analysis of population-based cross-sectional data

BMC Pregnancy and Childbirth, 2023
Background Breastfeeding has many health, economic and environmental benefits for both the infant and pregnant individual. Due to these benefits, the World Health Organization and Health Canada recommend exclusive breastfeeding for the first six months ...
Christina Ricci, Victoria Otterman, Terri-Lyn Bennett, Stephanie Metcalfe, Elizabeth Darling, Sonia Semenic, Susie Dzakpasu, for the Canadian Perinatal Surveillance System   +7 more
doaj   +1 more source

Impact of the coronavirus disease 2019 pandemic on breastfeeding during and at discharge from neonatal care: An observational cohort study

Pediatric Investigation, 2022
Importance During the coronavirus disease 2019 (COVID‐19) lockdown, changes in the visiting rules in neonatal units might have affected the initiation and continuation of breastfeeding.
Haslina Binti Abdul Hamid, Lisa Szatkowski, Helen Budge, Shalini Ojha   +3 more
doaj   +1 more source