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Strategies to sensitize cancer cells to immunotherapy
Human Vaccines & Immunotherapeutics, 2021 Recent years have seen the emergence of immunotherapy as a promising modality for treating a variety of cancers. However, the initial data have led to the ultimate reality that such a treatment does not work effectively in all cancers, nor does it ...
Andrew George +5 more
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BMC Psychology, 2022 Background The coach-coachee working alliance and coachee motivation seem important factors for achieving positive coaching results. Self-determination theory, specifically basic psychological need theory, has been proposed as a relevant framework for ...
Margriet Vermeiden +7 more
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Cancer Biology & Therapy, 2022 GSK-3β is a serine/threonine kinase implicated in tumorigenesis and chemotherapy resistance. GSK-3β blockade downregulates the NF-κB pathway, modulates immune cell PD-1 and tumor cell PD-L1 expression, and increases CD8 + T cell and NK cell function.
Andrew Hsu +11 more
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Genes and Longevity of Lifespan [PDF]
International Journal of Molecular Sciences, 2022 Aging is a complex process indicated by low energy levels, declined physiological activity, stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent developments in medical sciences and an increased availability of nutritional requirements has significantly increased the average human lifespan worldwide.
May Nasser Bin-Jumah +10 more
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Within-person structures of daily cognitive performance differ from between-person structures of cognitive abilities [PDF]
PeerJ, 2020 Over a century of research on between-person differences has resulted in the consensus that human cognitive abilities are hierarchically organized, with a general factor, termed general intelligence or “g,” uppermost.
Florian Schmiedek +3 more
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Nature Reviews Molecular Cell Biology, 2020 Increased expression of the circular RNA generated by the sulfateless gene (circSfl), and of the protein it encodes, can extend the lifespan of flies.
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Lifespan of neurons is uncoupled from organismal lifespan [PDF]
Proceedings of the National Academy of Sciences, 2013 Neurons in mammals do not undergo replicative aging, and, in absence of pathologic conditions, their lifespan is limited only by the maximum lifespan of the organism. Whether neuronal lifespan is determined by the strain-specific lifetime or can be extended beyond this limit is unknown.
Magrassi L, Leto K, Rossi F
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Normalized lifespan inequality: disentangling the longevity–lifespan variability nexus [PDF]
Genus, 2022 AbstractPrevious studies have documented a historically strong and negative association between countries’ life expectancy (i.e., average longevity) and length-of-life inequality (i.e., variability in ages at death). The relationship between both variables might be partially explained by life expectancy increasing at a faster pace than maximal length ...
Iñaki Permanyer, Jiaxin Shi
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Scientific Reports, 2021 Left ventricular remodeling due to pressure overload is associated with poor prognosis. Sacubitril/valsartan is the first-in-class Angiotensin Receptor Neprilysin Inhibitor and has been demonstrated to have superior beneficial effects in the settings of ...
Xiaofei Li +4 more
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N‐acetylglutamate synthase deficiency with associated 3‐methylglutaconic aciduria: A case report
JIMD Reports, 2022 N‐acetylglutamate synthase (NAGS) deficiency is a rare autosomal recessive disorder, which results in the inability to activate the key urea cycle enzyme, carbamoylphosphate synthetase 1 (CPS1).
Arthavan Selvanathan +10 more
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