Results 41 to 50 of about 351,585 (313)

Circulating S‐Glutathionylated cMyBP‐C as a Biomarker for Cardiac Diastolic Dysfunction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background cMyBP‐C (Cardiac myosin binding protein‐C) regulates cardiac contraction and relaxation. Previously, we demonstrated that elevated myocardial S‐glutathionylation of cMyBP‐C correlates with diastolic dysfunction (DD) in animal models.
Xiaoxu Zhou, Euy‐Myoung Jeong, Hong Liu, Bahaa Kaseer, Man Liu, Suvash Shrestha, Hafiz Imran, Kylie Kavanagh, Ning Jiang, Lori‐Ann Desimone, Feng Feng, Guangbin Shi, Go Eun Jeong, Anyu Zhou, Philip Stockwell, Samuel C. Dudley   +15 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Lifespan

, 2016
Data on lifespan for all individuals in ...
Boonekamp, Jelle J., Briga, Michael, Michael Briga (151448), Verhulst, Simon, Jelle Boonekamp (3371696), Simon Verhulst (143968), Jimeno, Blanca, Egbert Koetsier (151451), Blanca Jimeno (3371693), Koetsier, Egbert   +9 more
core   +1 more source

The integrated stress response in budding yeast lifespan extension [PDF]

, 2017
Aging is a complex, multi-factorial biological process shared by all living organisms. It is manifested by a gradual accumulation of molecular alterations that lead to the decline of normal physiological functions in a time-dependent fashion.
Jessica K. Tyler, Spike D.L. Postnikoff, Jay E. Johnson   +2 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Molecular evolution and functional characterization of Drosophila insulin-like peptides [PDF]

, 2010
Multicellular animals match costly activities, such as growth and reproduction, to the environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway plays key roles in growth, metabolism, stress resistance, reproduction, and ...
Gronke, S, Clarke, DF, Linda Partridge, Partridge, Linda, Andrews, T., Partridge, L., Broughton, S, Broughton, Susan, David-Francis Clarke, T Daniel Andrews, Grönke, S., Andrews, T Daniel, Grönke, Sebastian, Broughton, S., Partridge, L, Sebastian Grönke, Andrews, TD, Susan Broughton, Andrews, T. Daniel, Clarke , D., Clarke, David-Francis   +20 more
core   +1 more source

Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation. [PDF]

The value of normative models in research and clinical practice relies on their robustness and a systematic comparison of different modelling algorithms and parameters; however, this has not been done to date.
Boomsma, Dorret I, Boomsma, D., Buckner, R., Walter, H., Glahn, David C, Schumann, G., Frangou, Sophia, Boomsma, Dorret, Tamnes, Christian, Yu, Yuetong, Gruber, O., Crone, Eveline, Brodaty, H., Thompson, Paul, Brouwer, R., Glahn, David, Caseras, X., Thompson, Paul M, Wierenga, L., Crone, E., Glahn, D., Crivello, Fabrice, Walter, Henrik, Brouwer, Rachel M, New, Faye, Jahanshad, N., Qi, Y., Haas, S., Crone, Eveline A, New, F., Ge, Ruiyang, Fan, Y., Erk, Susanne, Tamnes, Christian K, Yu, Y., Ge, R., Qi, Yi Xuan, Qi, Yi, Buckner, Randy, Grotegerd, D., Tamnes, C., Thompson, P., Jahanshad, Neda, Haas, Shalaila, Haas, Shalaila S, Franke, Barbara, Grotegerd, Dominik, Brodaty, Henry, Brouwer, Rachel, Fisher, Simon E, Franke, B., Dannlowski, U., Fisher, S., Erk, S., Gao, Chuntong, Wierenga, Lara, Fisher, Simon, Gao, C., Gruber, Oliver, Schumann, Gunter, Chen, Shiyu, Chen, S., Wierenga, Lara M, Hulshoff Pol, Hilleke E, Dannlowski, Udo, Fan, Yu-Nan, Caseras, Xavier, Hulshoff Pol, Hilleke, Crivello, F., Hulshoff Pol, H., ENIGMA Lifespan Working Group, Frangou, S.   +71 more
core   +3 more sources

Cambridgeshire Lifespan Autism Spectrum Service Clinic: Managing Demand, Capacity and Flow of Referrals for Adult Autism Assessment

BJPsych Open
Aims Referrals for adult autism assessment to the Cambridgeshire Lifespan Autism Spectrum Service (CLASS) have increased from 430 in 2019 to 887 in 2023, with demand exceeding capacity.
Janine Robinson, Jasmine Taylor, Mark Squire, Andrea Woods, Irene James   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster [PDF]

, 2009
Background: Outcomes of lifespan studies in model organisms are particularly susceptible to variations in technical procedures. This is especially true of dietary restriction, which is implemented in many different ways among laboratories.
Linda Partridge, Partridge, L., Wong, Richard, Timothy M Bass, Partridge Linda, Grandison, R.C., Richard Wong, Wong, R., Tanimoto, H., Richard C Grandison, Bass, TM, Matthew D W Piper, Piper, M.D.W., Grandison, RC, Grandison, Richard C., Partridge, Linda, Wong, R, Bass Timothy M., Piper, MDW, Piper Matthew D. W., Partridge, L, Grandison Richard C., Bass, Timothy M., Piper, M. D W, Wong Richard, Bass, T.M.   +25 more
core   +1 more source