Results 41 to 50 of about 398,606 (255)

Implementation of a comprehensive sickle cell center leads to improved access to care and decreased acute care use

BMC Health Services Research
Background Sickle cell disease (SCD) is a lifespan condition associated with substantial morbidity, premature mortality, and high healthcare utilization, particularly due to acute pain crises and other severe complications.
Julie Kanter, Allison Plaxco, Najibah Galadanci, Gerhard Helleman, Rachel Klein, Jeffrey Lebensburger   +5 more
doaj   +1 more source

Circulating S‐Glutathionylated cMyBP‐C as a Biomarker for Cardiac Diastolic Dysfunction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background cMyBP‐C (Cardiac myosin binding protein‐C) regulates cardiac contraction and relaxation. Previously, we demonstrated that elevated myocardial S‐glutathionylation of cMyBP‐C correlates with diastolic dysfunction (DD) in animal models.
Xiaoxu Zhou, Euy‐Myoung Jeong, Hong Liu, Bahaa Kaseer, Man Liu, Suvash Shrestha, Hafiz Imran, Kylie Kavanagh, Ning Jiang, Lori‐Ann Desimone, Feng Feng, Guangbin Shi, Go Eun Jeong, Anyu Zhou, Philip Stockwell, Samuel C. Dudley   +15 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation. [PDF]

The value of normative models in research and clinical practice relies on their robustness and a systematic comparison of different modelling algorithms and parameters; however, this has not been done to date.
Boomsma, Dorret I, Boomsma, D., Buckner, R., Walter, H., Glahn, David C, Schumann, G., Frangou, Sophia, Boomsma, Dorret, Tamnes, Christian, Yu, Yuetong, Gruber, O., Crone, Eveline, Brodaty, H., Thompson, Paul, Brouwer, R., Glahn, David, Caseras, X., Thompson, Paul M, Wierenga, L., Crone, E., Glahn, D., Crivello, Fabrice, Walter, Henrik, Brouwer, Rachel M, New, Faye, Jahanshad, N., Qi, Y., Haas, S., Crone, Eveline A, New, F., Ge, Ruiyang, Fan, Y., Erk, Susanne, Tamnes, Christian K, Yu, Y., Ge, R., Qi, Yi Xuan, Qi, Yi, Buckner, Randy, Grotegerd, D., Tamnes, C., Thompson, P., Jahanshad, Neda, Haas, Shalaila, Haas, Shalaila S, Franke, Barbara, Grotegerd, Dominik, Brodaty, Henry, Brouwer, Rachel, Fisher, Simon E, Franke, B., Dannlowski, U., Fisher, S., Erk, S., Gao, Chuntong, Wierenga, Lara, Fisher, Simon, Gao, C., Gruber, Oliver, Schumann, Gunter, Chen, Shiyu, Chen, S., Wierenga, Lara M, Hulshoff Pol, Hilleke E, Dannlowski, Udo, Fan, Yu-Nan, Caseras, Xavier, Hulshoff Pol, Hilleke, Crivello, F., Hulshoff Pol, H., ENIGMA Lifespan Working Group, Frangou, S.   +71 more
core   +3 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Antenatal and Neonatal Management of Siblings With Carbonic Anhydrase VA Deficiency

JIMD Reports
Carbonic anhydrase VA (CAVA) deficiency (OMIM 114761) is an ultra‐rare inborn error of metabolism with fewer than 20 cases described. Affected infants present in the first days of life with hyperammonaemia, lactic acidosis, ketonaemia and encephalopathy.
Sophie Manoy, Tahlee Minto, Kalliope Demetriou, Matthew Lynch, Arthavan Selvanathan, Luke Jardine, Michelle Lipke, Carolyn Bursle, Anita Inwood, Jim McGill, David Coman   +10 more
doaj   +1 more source

Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation

Acta Neuropathologica Communications, 2022
A growing body of evidence supports the presence of a population of cells in glioblastoma (GBM) with a stem cell-like phenotype which shares certain biological markers with adult neural stem cells, including expression of SOX2, CD133 (PROM1), and NES ...
Nelli S. Lakis, Alexander S. Brodsky, Galina Karashchuk, Amanda J. Audesse, Dongfang Yang, Ashlee Sturtevant, Kara Lombardo, Ian Y. Wong, Ashley E. Webb, Douglas C. Anthony   +9 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The integrated stress response in budding yeast lifespan extension [PDF]

, 2017
Aging is a complex, multi-factorial biological process shared by all living organisms. It is manifested by a gradual accumulation of molecular alterations that lead to the decline of normal physiological functions in a time-dependent fashion.
Jessica K. Tyler, Spike D.L. Postnikoff, Jay E. Johnson   +2 more
core   +1 more source

Delivering yoga to people with hypertension in the UK: A qualitative study to explore yoga providers' knowledge, experiences, and attitudes

Health Science Reports, 2023
Background and Aims Yoga has become increasingly popular in the world and the UK for improving health and well‐being. A growing body of research suggests that yoga could be used to improve the management of hypertension in addition to current management ...
Gamze Nalbant, Zeinab M. Hassanein, Sarah Lewis, Kaushik Chattopadhyay   +3 more
doaj   +1 more source