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Neurogenesis and brain aging [PDF]
Reviews in the Neurosciences, 2019 Abstract Human aging affects the entire organism, but aging of the brain must undoubtedly be different from that of all other organs, as neurons are highly differentiated postmitotic cells, for the majority of which the lifespan in the postnatal period is equal to the lifespan of the entire organism.
Nickolay Isaev, Elisaveta E Genrikhs
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Sleep in the Aging Brain [PDF]
Brain Sciences, 2021 We have entered an era of a steep increase in the absolute and relative number of older people. This well-come phenomenon represents a major challenge for health care. However, maturational changes in sleep associated with aging do not easily appear as main factors, even though sleep alterations in the aging process lead to many detrimental ...
Gorgoni, Maurizio, Gennaro, Luigi De
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Diet moderates the effect of resting state functional connectivity on cognitive function
Scientific Reports, 2022 Past research suggests modifiable lifestyle factors impact structural and functional measures of brain health, as well as cognitive performance, but no study to date has tested the effect of diet on resting state functional connectivity (rsFC), and its ...
Alexandra M. Gaynor +8 more
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, 2013 An increasing number of persons live for nine or more decades and enjoy the benefits of a well-functioning brain until the end of their life. In that respect, the cognitive performance in later life and the quality maintenance of the brain are amazing biological phenomena.
Luiten, P. +3 more
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Scientific Reports, 2021 Here, we investigated the genetics of weighted functional brain network graph theory measures from 18,445 participants of the UK Biobank (44–80 years). The eighteen measures studied showed low heritability (mean h2 SNP = 0.12) and were highly genetically
Heidi Foo +6 more
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BMC Medical Research Methodology, 2018 Background Few studies have compared methods to correct for retest effects or practice effects in settings where an acute event could influence test performance, such as major surgery.
Annie M. Racine +7 more
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Group Intensive Cognitive Activation in Patients with Major or Mild Neurocognitive Disorder
Frontiers in Behavioral Neuroscience, 2016 Background: No standard protocols are available for cognitive rehabilitation in conditions like Major or Mild Neurocognitive disorder (M-NCD or m-NCD, respectively); however, preliminary data seem to indicate that such interventions might have cost ...
Simonetta ePanerai +9 more
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LDOC1 expression in fibroblasts of patients with Down syndrome
Open Life Sciences, 2015 Down syndrome (DS) is characterised by intellectual disability and is caused by trisomy 21. Apoptosis is a programmed cell death process and is involved in neurodegenerative diseases such as Alzheimer.
Salemi Michele +11 more
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Postgraduate Medical Journal, 2006 Abstract Ageing causes changes to the brain size, vasculature, and cognition. The brain shrinks with increasing age and there are changes at all levels from molecules to morphology. Incidence of stroke, white matter lesions, and dementia also rise with age, as does level of memory impairment and there are changes in levels of ...
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Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice
Translational Psychiatry, 2022 Apolipoprotein E ε4 (APOE4) is the primary genetic risk factor for the late-onset form of Alzheimer’s disease (AD). Although the reason for this association is not completely understood, researchers have uncovered numerous effects of APOE4 expression on ...
André Miguel Miranda +10 more
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