Results 11 to 20 of about 2,520,525 (306)

Insulin and brain aging

Menopausal Review, 2017
The world's population is living much longer than in the past. It is crucial to find as many pathological factors that deteriorate the health condition and well-being of elderly people as possible. Loss of activity and functions over time is typical for elderly people.
Agnieszka Baranowska-Bik, Wojciech Bik
openaire   +4 more sources

Evolution of the Aging Brain Transcriptome and Synaptic Regulation [PDF]

, 2008
Alzheimer's disease and other neurodegenerative disorders of aging are characterized by clinical and pathological features that are relatively specific to humans.
Dakin Kelly A., Isaacs Adrian, Prolla Tomas A., Pan, Y, Gabuzda Dana H., Geula Chengiz, Li, C, Jianbin Wang, Pan Ying, Wang, J, Dakin, KA, Bruce A Yankner, Adrian Isaacs, Ying Pan, Isaacs, A, Gabuzda, DH, Tao Lu, Yankner Bruce A., Cheng Li, Geula, C, Tomas A Prolla, Loerch, PM, Prolla, TA, Lu, T, Yankner, BA, Li Cheng, Wang Jianbin, Chengiz Geula, Kelly A Dakin, Dana H Gabuzda, Patrick M Loerch, Loerch Patrick M., Vann, JM, Lu Tao, Vann James M., James M Vann   +35 more
core   +2 more sources

Reproducibility of serum cytokines in an elderly population

Immunity & Ageing, 2020
Background It is important to assess the temporal reproducibility of circulating cytokines for their utility in epidemiological studies. However, existing evidence is limited and inconsistent, especially for the elderly population.
Jing Guo, Nicole Schupf, Richard P. Mayeux, Yian Gu   +3 more
doaj   +1 more source

Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

Molecular Neurodegeneration, 2019
Background Soluble aggregates of oligomeric forms of tau protein (oTau) have been associated with impairment of synaptic plasticity and memory in Alzheimer’s disease.
Erica Acquarone, Elentina K. Argyrousi, Manon van den Berg, Walter Gulisano, Mauro Fà, Agnieszka Staniszewski, Elisa Calcagno, Elisa Zuccarello, Luciano D’Adamio, Shi-Xian Deng, Daniela Puzzo, Ottavio Arancio, Jole Fiorito   +12 more
doaj   +1 more source

Endothelial and Astrocytic Support by Human Bone Marrow Stem Cell Grafts into Symptomatic ALS Mice towards Blood-Spinal Cord Barrier Repair

Scientific Reports, 2017
Vascular pathology, including blood-CNS barrier (B-CNS-B) damage via endothelial cell (EC) degeneration, is a recently recognized hallmark of Amyotrophic Lateral Sclerosis (ALS) pathogenesis. B-CNS-B repair may be a new therapeutic approach for ALS. This
Svitlana Garbuzova-Davis, Crupa Kurien, Avery Thomson, Dimitri Falco, Sohaib Ahmad, Joseph Staffetti, George Steiner, Sophia Abraham, Greeshma James, Ajay Mahendrasah, Paul R. Sanberg, Cesario V. Borlongan   +11 more
doaj   +1 more source

Eyeballing stroke: Blood flow alterations in the eye and visual impairments following transient middle cerebral artery occlusion in adult rats

Cell Transplantation, 2020
Middle cerebral artery occlusion in rodents remains a widely used model of ischemic stroke. Recently, we reported the occurrence of retinal ischemia in animals subjected to middle cerebral artery occlusion, owing in part to the circulatory juxtaposition ...
Jea-young Lee, Vanessa Castelli, Brooke Bonsack, Julián García-Sánchez, Chase Kingsbury, Hung Nguyen, Naoki Tajiri, Cesar V. Borlongan   +7 more
doaj   +1 more source

Effects of Exercise on Gene-Expression Profile in the Rat Hippocampus

Neurobiology of Disease, 2001
Exercise has beneficial effects on brain function, including the promotion of plasticity and the enhancement of learning and memory performance. Previously we found that exercise increases the expression of certain neurotrophic factors including brain ...
Liqi Tong, Hong Shen, Victoria M. Perreau, Robert Balazs, Carl W. Cotman   +4 more
doaj   +1 more source

Deep learning improves utility of tau PET in the study of Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Introduction Positron emission tomography (PET) imaging targeting neurofibrillary tau tangles is increasingly used in the study of Alzheimer's disease (AD), but its utility may be limited by conventional quantitative or qualitative evaluation techniques ...
James Zou, David Park, Aubrey Johnson, Xinyang Feng, Michelle Pardo, Jeanelle France, Zeljko Tomljanovic, Adam M. Brickman, Devangere P. Devanand, José A. Luchsinger, William C. Kreisl, Frank A. Provenzano, for the Alzheimer's Disease Neuroimaging Initiative   +12 more
doaj   +1 more source

Polyunsaturated Fatty Acid and S-Adenosylmethionine Supplementation in Predementia Syndromes and Alzheimer's Disease: A Review

The Scientific World Journal, 2009
A growing body of evidence indicates that nutritional supplements can improve cognition; however, which supplements are effective remains controversial.
Francesco Panza, Vincenza Frisardi, Cristiano Capurso, Alessia D'Introno, Anna M. Colacicco, Alessandra Di Palo, Bruno P. Imbimbo, Gianluigi Vendemiale, Antonio Capurso, Vincenzo Solfrizzi   +9 more
doaj   +1 more source

Translating intracarotid artery transplantation of bone marrow‐derived NCS‐01 cells for ischemic stroke: Behavioral and histological readouts and mechanistic insights into stem cell therapy

Stem Cells Translational Medicine, 2020
The present study used in vitro and in vivo stroke models to demonstrate the safety, efficacy, and mechanism of action of adult human bone marrow‐derived NCS‐01 cells.
Yuji Kaneko, Jea‐Young Lee, Naoki Tajiri, Julian P. Tuazon, Trenton Lippert, Eleonora Russo, Seong‐Jin Yu, Brooke Bonsack, Sydney Corey, Alexandreya B. Coats, Chase Kingsbury, Thomas N. Chase, Minako Koga, Cesar V. Borlongan   +13 more
doaj   +1 more source