Results 51 to 60 of about 398,606 (255)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Hippocampal-cortical functional connectivity during memory encoding and retrieval

NeuroImage, 2023
Memory encoding and retrieval are critical sub-processes of episodic memory. While the hippocampus is involved in both, less is known about its connectivity with the neocortex during memory processing in humans.
Liisa Raud, Markus H. Sneve, Didac Vidal-Piñeiro, Øystein Sørensen, Line Folvik, Hedda T. Ness, Athanasia M. Mowinckel, Håkon Grydeland, Kristine B. Walhovd, Anders M. Fjell   +9 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mouse Lifespan Synaptome Atlas code repository

, 2020
Matlab code to generate figures for the manuscript 'Cizeron, M.*, Qiu, Z. *, Koniaris, B., Gokhale, R., Komiyama, N., Fransén, E., Grant, S.G.N. (2020). A brain-wide atlas of synapses across the mouse lifespan. (* Equal contribution)'
Qiu, Ricky, Zhen Ricky Qiu, School of Regeneration and Repair, Edinburgh Neuroscience, Grant, Seth G.N.; id_orcid, Centre for Clinical Brain Sciences, Seth G.N. Grant   +6 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A study on extending technologies lifespan for the environment safety

, 2021
The technological devices have become a big burden for the environment. Today, there is an agreement among researchers that this issue must be considered from a life cycle perspective. The best scenario would be to extend the devices lifespan.
Amal Labidi, Ikuo Tanabe, Satoshi Takahashi   +2 more
core   +1 more source

Men’s recollections of child and adolescent parental bonding and prospective associations with shame in adulthood

Discover Psychology
Few studies have investigated developmental origins of shame in men, yet experiences of shame are linked to psychological distress and maladaptive behaviors. Here, we examine recollections of parental care and control during childhood and adolescence and
Georgia A. Zoumboulis, Kayla A. Mansour, Lauren M. Francis, Christopher J. Greenwood, Craig A. Olsson, Gessica O. Misuraca, Jacqui A. Macdonald   +6 more
doaj   +1 more source

Aged brain and neuroimmune responses to COVID-19: post-acute sequelae and modulatory effects of behavioral and nutritional interventions

Immunity & Ageing, 2023
Advanced age is one of the significant risk determinants for coronavirus disease 2019 (COVID-19)-related mortality and for long COVID complications. The contributing factors may include the age-related dynamical remodeling of the immune system, known as ...
Ludmila Müller, Svetlana Di Benedetto
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Structural signature of trauma: white matter volume in right inferior frontal gyrus is positively associated with use of expressive suppression in recently traumatized individuals

European Journal of Psychotraumatology, 2021
Background: Differences in grey and white matter structure have been found between trauma-exposed individuals with and without PTSD. Yet, it remains unclear which functional processes are underlying these volumetric changes.
Katharina Wermuth, Dominik Ülsmann, Janine Borngräber, Jürgen Gallinat, Olaf Schulte-Herbrüggen, Simone Kühn   +5 more
doaj   +1 more source