Results 101 to 110 of about 351,585 (313)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Lifespan development

, 2009
Lifespan Development, First Australian Edition, explores human physical, cognitive and social development within the Australian and New zealand contexts.
Hoffnung, Robert J., Burton Smith, Rosanne, Ward, Lynn, Hine, Alison, Hoffnung, Michelle, Quinn, Andrea, Seifert, Kelvin L.   +6 more
core  

Metamemory Across the Lifespan

Part of a longitudinal investigation into how people's thinking develops over time and across the lifespan. Recruiting participants ages 10+ to partake in testing sessions over the course of multiple years. The larger study taps various aspects of social
Monika Undorf, Carolyn Baer, Daniel M Bernstein, M. Kyle Matsuba, Lifespan Cognition Lab   +4 more
core   +1 more source

Fecundity and lifespan manipulations in Caenorhabditis elegans using exogenous peptides

, 2008
In this study using Caenorhabditis elegans, we have been able to suppress (>60%) and enhance (>40%) fecundity (number of offspring) while extending lifespan by a fifth, by administering synthetic peptides to the aqueous medium in ...
Keith G. Davies, Davies, K. G., John E. Hart, Hart, J. E.   +3 more
core   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Three years of pandemic stress and staffing challenges: a retrospective qualitative study of COVID-19 impacts on frontline healthcare workers’ mental health and wellbeing

BMC Psychiatry
Background Healthcare systems have faced unprecedented demand over the course of the COVID-19 pandemic, placing significant burdens on frontline doctors, nurses, and support staff.
Brian En Chyi Lee, Mathew Ling, Leanne Boyd, Craig A. Olsson, Hannah Michelle LaFontaine Harvey, Jade Sheen   +5 more
doaj   +1 more source

Nutrition as a systems regulator of brain aging trajectories

Frontiers in Molecular Neuroscience
Nutrition is increasingly recognized as a central determinant of brain health across the lifespan. Beyond their classical roles as energetic substrates, dietary components and their bioactive metabolites may act as signaling molecules capable of ...
Ludmila Müller, Svetlana Di Benedetto, Viktor Müller   +2 more
doaj   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Lifespan and testosterone [PDF]

Nature, 1993
E, Nieschlag, S, Nieschlag, H M, Behre
openaire   +2 more sources

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source