Results 91 to 100 of about 398,606 (255)

The value of social networks for men: concurrent and prospective associations with psychological wellbeing

BMC Psychology
Background There is increased attention on psychological wellbeing as a public health priority. Here, we examine concurrent and prospective associations between social network connections and psychological wellbeing in a community sample of Australian ...
Kayla Mansour, Christopher J Greenwood, Lauren M Francis, Gessica Misuraca, Khya Marabel-Whitburn, Craig A Olsson, Jacqui A Macdonald   +6 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Modulation of the glyoxalase system in the aging model Podospora anserina : effects on growth and lifespan [PDF]

, 2011
The eukaryotic glyoxalase system consists of two enzymatic components, glyoxalase I (lactoylglutathionelyase) and glyoxalase II (hydroxyacylglutathione hydrolase). These enzymes are dedicated to the removal of toxic alpha-oxoaldehydes like methylglyoxal (
Ricciardi, Filomena, Mack, Sandra J., Gispert, Suzana, Osiewacz, Heinz D., Scheckhuber, Christian Quintus, Strobel, Ingmar   +5 more
core   +1 more source

Three years of pandemic stress and staffing challenges: a retrospective qualitative study of COVID-19 impacts on frontline healthcare workers’ mental health and wellbeing

BMC Psychiatry
Background Healthcare systems have faced unprecedented demand over the course of the COVID-19 pandemic, placing significant burdens on frontline doctors, nurses, and support staff.
Brian En Chyi Lee, Mathew Ling, Leanne Boyd, Craig A. Olsson, Hannah Michelle LaFontaine Harvey, Jade Sheen   +5 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Metamemory Across the Lifespan

Part of a longitudinal investigation into how people's thinking develops over time and across the lifespan. Recruiting participants ages 10+ to partake in testing sessions over the course of multiple years. The larger study taps various aspects of social
Monika Undorf, Carolyn Baer, Daniel M Bernstein, M. Kyle Matsuba, Lifespan Cognition Lab   +4 more
core   +1 more source

Live fast, die soon: cell cycle progression and lifespan in yeast cells

, 2015
Our understanding of lifespan has benefited enormously from the study of a simple model, the yeast Saccharomyces cerevisiae. Although a unicellular organism, yeasts undergo many of the processes directly related with aging that to some extent are ...
Javier Jiménez, Josep Clotet, Samuel Bru, Mariana PC Ribeiro   +3 more
core   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source