Results 41 to 50 of about 520,305 (247)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Torsional Vibration Stress and Fatigue Strength Analysis of Marine Propulsion Shafting System Based on Engine Operation Patterns

Journal of Marine Science and Engineering, 2020
Modern merchant ships use marine propulsion systems equipped with an ultra-long-stroke diesel engine that directly drives a large slow-turning propeller.
Myeong-Ho Song, Xuan Duong Pham, Quang Dao Vuong   +2 more
doaj   +1 more source

Time-Dependent Dielectric Breakdown of Commercial 1.2 kV 4H-SiC Power MOSFETs

IEEE Journal of the Electron Devices Society, 2021
Constant-voltage time-dependent dielectric breakdown (TDDB) measurements are performed on recently manufactured commercial 1.2 kV 4H-SiC power metal-oxide-semiconductor (MOS) field-effect transistors (MOSFETs) from three vendors.
Tianshi Liu, Shengnan Zhu, Marvin H. White, Arash Salemi, David Sheridan, Anant K. Agarwal   +5 more
doaj   +1 more source

Growth Maximising Patent Lifetime [PDF]

SSRN Electronic Journal, 2000
Using a vertical differentiation model of endogenous growth with stochastic R&D activity, we characterise the optimal patent lifetime a government would set in order to maximise economic growth. We show that a finite patent lifetime does exist and is unique provided that the expected rate of return from R&D is sufficiently large.
Alberto BUCCI, H. Cagri SAGLAM
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Synergizing physics and machine learning for advanced battery management

Communications Engineering
Improving battery health and safety motivates the synergy of a powerful duo: physics and machine learning. Through seamless integration of these disciplines, the efficacy of mathematical battery models can be significantly enhanced.
Manashita Borah, Qiao Wang, Scott Moura, Dirk Uwe Sauer, Weihan Li   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Time-resolved Photoluminescence Characterisation of GaAs/AlxGa1–xAs Structures Designed for Microwave and Terahertz Detectors

Medžiagotyra, 2014
The time-resolved photoluminescence of donor Si-doped GaAs/AlxGa1-xAs (x = 0.3 0.25, 0.2, 0.1) structures designed for microwave and terahertz detectors have been investigated at T = 3.6 K temperature.
Aurimas ČERŠKUS, Viktorija NARGELIENĖ, Algirdas SUŽIEDĖLIS, Steponas AŠMONTAS, Jonas GRADAUSKAS, Benas KUNDROTAS, Roma RINKEVIČIENĖ   +6 more
doaj   +1 more source

A Detailed Study of Electronic and Dynamic Properties of Noble Gas–Oxygen Molecule Adducts

Molecules, 2022
In this work, the binding features of adducts formed by a noble gas (Ng = He, Ne, Ar, Kr, Xe, and Rn) atom and the oxygen molecule (O2) in its ground Σg−3, in the past target of several experimental studies, have been characterized under different ...
Caio Vinícius Sousa Costa, Guilherme Carlos Carvalho de Jesus, Luiz Guilherme Machado de Macedo, Fernando Pirani, Ricardo Gargano   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source