Results 101 to 110 of about 1,008,319 (276)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Powered-lift aircraft technology [PDF]
Powered lift aircraft have the ability to vary the magnitude and direction of the force produced by the propulsion system so as to control the overall lift and streamwise force components of the aircraft, with the objective of enabling the aircraft to ...
Deckert, W. H., Franklin, J. A.
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Ligation of fistulas of rectum in intersphincteric layer: the pilot study
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2012 Aim of investigation. Ligation of fistulous tract in intersphincteric layer (Ligation of Intersphincteric Fistula Tract – LIFT) – is a new method of surgical treatment of trans- and extrasphincter fistulas.
M. N. Chekanov +2 more
doaj
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
NUMERICAL ANALYSIS AND EXPERIMENTAL INVESTIGATION OF DISK SPRING CONFIGURATIONS WITH REGARD TO LOAD CAPACITY OF SAFETY PROGRESSIVE GEARS [PDF]
Applied Computer Science, 2016 The paper investigates the effect of various disk spring package configurations on brake load of safety progressive gears. The numerical analysis is performed using the Abaqus/CAE software and the designed 3D models.
Paweł LONKWIC +2 more
doaj
Iterative calculus on tangent floors
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2016 Tangent fibrations generate a “multi-floored tower”, while raising from one of its floors to the next one, one practically reiterates the previously performed actions. In this way, the "tower" admits a ladder-shaped structure. Raising to the first floors
Balan Vladimir +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Low-speed power effects on advanced fighter configurations with two-dimensional deflected thrust [PDF]
Wind-tunnel studies at the Langley Research Center have shown that significant increases in maximum lift coefficient and stability and decreases in drag due to lift are obtained when two-dimensional vectored thrust is used in conjuction with a close ...
Paulson, J. W., Jr. +2 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source