Results 111 to 120 of about 237,722 (291)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design of a High-Lift System for a Laminar Wing
, 2013 The design of high-lift (HL) systems represents a challenging task within the aerospace community, due to its multidisciplinary, multi-objective and multi-point nature.
Wild, Jochen +5 more
core
NUMERICAL ANALYSIS AND EXPERIMENTAL INVESTIGATION OF DISK SPRING CONFIGURATIONS WITH REGARD TO LOAD CAPACITY OF SAFETY PROGRESSIVE GEARS [PDF]
Applied Computer Science, 2016 The paper investigates the effect of various disk spring package configurations on brake load of safety progressive gears. The numerical analysis is performed using the Abaqus/CAE software and the designed 3D models.
Paweł LONKWIC +2 more
doaj
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Investigation of relationship between drag and lift coefficients for a generic car model [PDF]
, 2014 The paper presents a study of aerodynamic characteristics of a car, which has the simplified geometric shape, so called Ahmed body. Flow around the body and the influence of its rear slant angle on drag are widely studied by numerous researchers. However,
MASSOUH, Fawaz, DOBREV, Ivan
core
Large scale separation flow control experiments within the German Flow Control Network
, 2009 This is an overview on flow control experiments for flow separation control conducted in the DNW-NWB atmospheric low-speed wind tunnel performed within the German Flow Control Network. Emphasis is given on the experimental setup using the DLR F15 wall-to-
Wild, Jochen +9 more
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source