Results 131 to 140 of about 237,722 (291)

Active control with dielectric barrier discharge actuators applied to high-lift devices

open access: yes, 2013
An experimental investigation examined the capability of dielectric barrier discharge (DBD) actuators to control a high-lift device system. Aerodynamic tests investigated the potential of utilising the actuator to control the flap side-edge vortex flow ...
Chappell, S.
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

The aggregate labor market effects of the Swedish knowledge lift program [PDF]

open access: yes
The Swedish adult education program known as the Knowledge Lift (1997-2002) was unprecedented in its size and scope, aiming to raise the skill level of large numbers of low-skill workers.
Vroman, Susan   +2 more
core  

Suppression of stall on high-camber flap using upper-surface blowing [PDF]

open access: yes, 2011
For many years, high-lift devices of an aeroplane have been employed to enhancing the aerodynamic performance of the wing during take-off and landing. But their complex geometries not only increase the design and manufacture cost, but also result in ...
Fang, Li
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Active Flow Separation Control on a High-Lift Wing-Body Configuration - Part 1: Baseline Flow and Constant Blowing

open access: yes, 2011
This paper describes the influence of grid resolution and turbulence modeling for a 3D transport aircraft in high lift configuration with massive flap separation.
Breitenstein, Wiebke   +4 more
core  

Uma proposta para o controle automático da repartida de poços operando por gas lift contínuo [PDF]

open access: yes, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Automação e Sistemas, Florianópolis, 2009A repartida de poços é um procedimento de alta complexidade.
Gonzaga, Carlos Alberto Cavichioli
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

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