Results 141 to 150 of about 113,829 (241)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Inertial Particle Migration in Contraction-Expansion Microchannels: Effects of Rectangular and Hook-Shaped Microstructures on Secondary Flow and Inertial Lift Competition. [PDF]

Micromachines (Basel)
Liu Q, Fang H, Zhang Y, Wang H, Han S, Huang D.   +5 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Self-adaptive and configurable transfer printing of flexible electronics via rheology of liquid foam. [PDF]

Sci Adv
Hu X, Wang S, Zhu Y, Liu J, Hong W, Yan X, Che L, Li M, Liu Z, Liu H, Yang Z, Wang X, Yin J, Xie Z, Wu M, Liu J.   +15 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

V3 midface lifting through a subciliary approach: a three-vector physiologic repositioning technique for midface rejuvenation, lower eyelid support, and lower lid-malar contour improvement. [PDF]

Front Surg
Chen A, Wang J, Liu K, Zhang F, Xie J.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Wings with stiffness and stroke variations enabling efficient flight and swimming for flapping-wing robots. [PDF]

Natl Sci Rev
Xiang Y, Gong Z, Yang C, Hou L, Zhang Z, Hong Y, Gu Z, Gu L, Shi Y, Tao B, Ding H.   +10 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Lithographic patterning of conformal thin films on 3D structures using Scaffold-architected Lift-off masks. [PDF]

Nat Commun
Liu X, Che Z, Maj Z, Lai LL, Gylfason KB, Dubois V, N Raja S, Stemme G, Niklaus F.   +8 more
europepmc   +1 more source