Results 101 to 110 of about 116,681 (302)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Study of alternative geometries for fluidic oscillators by means of computational fluid mechanics [PDF]

, 2015
Se estudiará el fllujo en el interior de osciladores fluídicos mediante el uso de un código comercial de Mecánica de Fluidos Computacional.Se estudiarán diferentes diseños y se compararán sus rendimientos.1. Documentación y estudio del estado del arte. 2.
Baucells Fuster, Xavier
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Aircraft Wings and Morphing–Evolution of the Concepts

Encyclopedia
This encyclopedia entry provides an updated appreciation of the evolution of morphing aircraft wings, organized as follows: first, lift concepts are briefly examined; second, patents related to lift enhancement are discussed, showcasing existing ...
Sérgio M. O. Tavares, Pedro V. Gamboa, Paulo M. S. T. de Castro   +2 more
doaj   +1 more source

Enhanced Euclidean supersymmetry, 11D supergravity and $SU(\infty)$ Toda equation

, 2013
We show how to lift solutions of Euclidean Einstein-Maxwell equations with non-zero cosmological constant to solutions of eleven-dimensional supergravity theory with non-zero fluxes.
Dunajski, Maciej, Gutowski, Jan, Sabra, Wafic   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Inverse transonic airfoil design methods including boundary layer and viscous interaction effects [PDF]

A body-fitted grid embedment technique applicable to inviscid transonic airfoil flow field analysis was developed and verified through a series of tests. Test cases used to verify the technique show that the accuracy of the solution was increased by grid
Carlson, L. A.
core   +1 more source

Progress and development of Coanda jet and vortex cell for aerodynamic surface circulation control - an overview [PDF]

, 2013
Coandă jet has always been referred to in the consideration of various flow control methods to enhance aerodynamic performance, i.e. to enhance lift, reduce drag and delay stall at higher angle of attack, along with continuous, synthetic and pulsed jets,
Djojodihardjo, Harijono
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source