Results 271 to 280 of about 363,417 (316)

Computer biochemistry and molecular physiology of the natural peptide ligands: different functional groups

open access: closed, 2006
The similarity in the functional spectra of many endogenous regulatory oligopeptides [1] allows the assumption that these molecules possess some common physicochemical properties. These properties provide the basis for the interaction of an oligopeptide with a particular set of receptor structures, and this interaction is the initial step of the ...
Andrey A. Zamyatnin, Olga L. Voronina
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Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydrooripavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry, biochemistry, and pharmacology

open access: closedJournal of Medicinal Chemistry, 1986
N-Allyl-, N-(cyclopropylmethyl)-, and N-propyl-endo-ethenotetrahydronororipavines (N-substituted 6,14-endo-etheno-4,5-epoxy-3-hydroxy-6-methoxymorphinans) were synthesized with potential acylating or alkylating moieties at the C-7 position (isothiocyanato, (bromoacetyl)amino, and (methoxyfumaroyl)amino) and examined in vivo for their narcotic agonist ...
Ralph A. Lessor   +9 more
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Equilibrium Gel Filtration Chromatography for the Measurement of Protein-Ligand Binding in the Undergraduate Biochemistry Laboratory

open access: closedJournal of Chemical Education, 2005
Equilibrium gel filtration liquid chromatography is a technique used for the quantitation of ligand binding. We have designed an experiment for the senior undergraduate laboratory using this technique for the measurement of the binding of ATP to cytochrome c.
Douglas B. Craig
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ChemInform Abstract: Polymer‐Immobilized Carbohydrate Ligands: Versatile Chemical Tools for Biochemistry and Medical Sciences

open access: closedChemInform, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nicolai V. Bovin, Hans‐Joachim Gabius
openalex   +4 more sources

Isocyanide in Biochemistry? A Theoretical Investigation of the Electronic Effects and Energetics of Cyanide Ligand Protonation in [FeFe]‐Hydrogenases

open access: closedChemistry – A European Journal, 2011
AbstractThe presence of Fe‐bound cyanide ligands in the active site of the proton‐reducing enzymes [FeFe]‐hydrogenases has led to the hypothesis that such Brønsted–Lowry bases could be protonated during the catalytic cycle, thus implying that hydrogen isocyanide (HNC) might have a relevant role in such crucial microbial metabolic paths.
Claudio Greco   +4 more
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Teaching Upper-Division Biochemistry Students the Role of Noncovalent Interactions and Ligand Structure in DNA Binding

open access: closedJournal of Chemical Education, 2013
The experiment described here uses the binding of cyanine dyes to DNA as a model system for demonstrating the role that both ligand structure and noncovalent interactions play in DNA binding. Upper-division biochemistry laboratory students observe changes in absorbance and fluorescence spectra when small molecules bind either in the minor groove of DNA
Kristen C. Roy
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Studying Cooperative Ligand Binding in the Undergraduate Biochemistry Laboratory: Oxygen–Hemoglobin Dissociation Revisited

open access: closedJournal of Chemical Education, 2015
The interaction between oxygen and hemoglobin is a classic example of a cooperative ligand-binding process. This gaseous-ligand binding process may be studied in the undergraduate laboratory with a variable-pressure cuvette apparatus. An updated method is described to assemble a variable-pressure cuvette apparatus composed of inexpensive supplies and ...
Megan K. M. Young, Theodore J. Gries
openalex   +3 more sources

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