Results 31 to 40 of about 369,161 (297)

A Diffusion-Based Approach to Geminate Recombination of Heme Proteins with Small Ligands [PDF]

, 2002
A model of postphotodissociative monomolecular (geminate) recombination of heme proteins with small ligands (NO, O2 or CO) is represented. The non-exponential decay with time for the probability to find a heme in unbound state is interpreted in terms of ...
Abadan, Anfinrud, Ansari, Ansari, Antonioni, Austin, Baldwin, Berlin, Bonaventura, Bruha, Cameron, Case, Chernoff, Cotes, Dadusc, Das, Dasgupta, Doster, Dzhagarov, Dzhagarov, Dzhagarov, Dzhagarov, Eaton, Elber, Fermi, Frauenfelder, Frauenfelder, Frauenfelder, Gallo, Gibson, Gibson, Hasinoff, Henry, Ho, Horbach, Johnson, Johnson, Jost, Kimanaka, Kottalam, Kuczera, Lepeshkevich, Lim, Lindqvist, Lukin, Marden, Morris, Muller, Murray, Olson, Olson, Perutz, Perutz, Perutz, Petrich, Potter, Quillin, Rifkind, Rodgers, Schaad, Schlichting, Shaanan, Springer, Starovoitov, Steinbach, Steinbach, Straub, Yamamoto, Yang, Ye   +69 more
core   +2 more sources

Phytosterol, Lipid and Phenolic Composition, and Biological Activities of Guava Seed Oil

Molecules, 2020
Plant seeds have been found to contain bioactive compounds that have potential nutraceutical benefits. Guava seeds (Psidium guajava) are by-products in the beverage and juice industry; however, they can be utilized for a variety of commercial purposes ...
Adchara Prommaban, Niramon Utama-ang, Anan Chaikitwattana, Chairat Uthaipibull, John B. Porter, Somdet Srichairatanakool   +5 more
doaj   +1 more source

Site-Differentiated Iron–Sulfur Cluster Ligation Affects Flavin-Based Electron Bifurcation Activity

Metabolites, 2022
Electron bifurcation is an elegant mechanism of biological energy conversion that effectively couples three different physiologically relevant substrates.
Courtney E. Wise, Anastasia E. Ledinina, Carolyn E. Lubner   +2 more
doaj   +1 more source

Functional selectivity of GPCR-directed drug action through location bias. [PDF]

, 2017
G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco, Huang, Bo, Irannejad, Roshanak, Mika, Delphine, Pessino, Veronica, von Zastrow, Mark, Wedegaertner, Philip B.   +6 more
core   +3 more sources

Structural and energetic effects of A2A adenosine receptor mutations on agonist and antagonist binding.

PLoS ONE, 2014
To predict structural and energetic effects of point mutations on ligand binding is of considerable interest in biochemistry and pharmacology. This is not only useful in connection with site-directed mutagenesis experiments, but could also allow ...
Henrik Keränen, Hugo Gutiérrez-de-Terán, Johan Åqvist   +2 more
doaj   +1 more source

Recent Advances in Optical DNA Biosensors Technology

CHIMIA, 2005
Recent advances in nucleic acids-based biosensors have led to the development of DNA biosensors for DNA hybridisation detection and for nucleic acid–ligand binding studies.
Bambang Kuswandi, Sara Tombelli, Giovanna Marazza, Marco Mascini   +3 more
doaj   +1 more source

Theoretical Evaluation of Novel Thermolysin Inhibitors from Bacillus thermoproteolyticus. Possible Antibacterial Agents

Molecules, 2021
The search for new antibacterial agents that could decrease bacterial resistance is a subject in continuous development. Gram-negative and Gram-positive bacteria possess a group of metalloproteins belonging to the MEROPS peptidase (M4) family, which is ...
Emilio Lamazares, Desmond MacLeod-Carey, Fernando P. Miranda, Karel Mena-Ulecia   +3 more
doaj   +1 more source

Ligand Modulation of Lateral Segregation of a G-Protein-Coupled Receptor into Lipid Microdomains in Sphingomyelin/Phosphatidylcholine Solid-Supported Bilayers [PDF]

Biochemistry, 2005
A growing body of evidence supports the idea that the plasma membrane bilayer is characterized by a laterally inhomogeneous mixture of lipids, having an organized structure in which lipid molecules segregate into small domains or patches. Such microdomains are characterized by high contents of sphingolipids that form thicker liquid-ordered regions that
Gordon Tollin, Isabel D. Alves, Zdzislaw Salamon, Victor J. Hruby   +3 more
openaire   +5 more sources

Investigation of Structural Dynamics of Enzymes and Protonation States of Substrates Using Computational Tools. [PDF]

, 2016
This review discusses the use of molecular modeling tools, together with existing experimental findings, to provide a complete atomic-level description of enzyme dynamics and function.
Chang, Chia-En A, Huang, Yu-Ming M, Mueller, Leonard J, You, Wanli   +3 more
core   +2 more sources

4-[(E)-2-(1-Pyrenyl)Vinyl]Pyridine Complexes: How to Modulate the Toxicity of Heavy Metal Ions to Target Microbial Infections

Molecules
Pyrene derivatives are regularly proposed for use in biochemistry as dyes due to their photochemical characteristics. Their antibacterial properties are, however, much less well understood. New complexes based on 4-[(E)-2-(1-pyrenyl)vinyl]pyridine (PyPe)
Justine V. Schwarte, Aurélien Crochet, Katharina M. Fromm   +2 more
doaj   +1 more source