Results 61 to 70 of about 379,006 (309)

Analyzing the Catalytic Role of Active Site Residues in the Fe-type Nitrile Hydratase from \u3cem\u3eComamonas testosteroni\u3c/em\u3e Ni1 [PDF]

, 2015
A strictly conserved active site arginine residue (αR157) and two histidine residues (αH80 and αH81) located near the active site of the Fe-type nitrile hydratase from Comamonas testosteroni Ni1 (CtNHase), were mutated. These mutant enzymes were examined
Chan, Hei, Holz, Richard C., Krzywda, Karoline, Liu, Dali, Martinez, Salette, Opalka, Veronika, Wu, Rui   +6 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

A Diffusion-Based Approach to Geminate Recombination of Heme Proteins with Small Ligands [PDF]

, 2002
A model of postphotodissociative monomolecular (geminate) recombination of heme proteins with small ligands (NO, O2 or CO) is represented. The non-exponential decay with time for the probability to find a heme in unbound state is interpreted in terms of ...
Abadan, Anfinrud, Ansari, Ansari, Antonioni, Austin, Baldwin, Berlin, Bonaventura, Bruha, Cameron, Case, Chernoff, Cotes, Dadusc, Das, Dasgupta, Doster, Dzhagarov, Dzhagarov, Dzhagarov, Dzhagarov, Eaton, Elber, Fermi, Frauenfelder, Frauenfelder, Frauenfelder, Gallo, Gibson, Gibson, Hasinoff, Henry, Ho, Horbach, Johnson, Johnson, Jost, Kimanaka, Kottalam, Kuczera, Lepeshkevich, Lim, Lindqvist, Lukin, Marden, Morris, Muller, Murray, Olson, Olson, Perutz, Perutz, Perutz, Petrich, Potter, Quillin, Rifkind, Rodgers, Schaad, Schlichting, Shaanan, Springer, Starovoitov, Steinbach, Steinbach, Straub, Yamamoto, Yang, Ye   +69 more
core   +2 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

The Biochemical Properties of Manganese in Plants

Plants, 2019
Manganese (Mn) is an essential micronutrient with many functional roles in plant metabolism. Manganese acts as an activator and co-factor of hundreds of metalloenzymes in plants.
Sidsel Birkelund Schmidt, Søren Husted
doaj   +1 more source

Evaluation of new antihypertensive drugs designed in silico using Thermolysin as a target

Saudi Pharmaceutical Journal, 2020
The search for new therapies for the treatment of Arterial hypertension is a major concern in the scientific community. Here, we employ a computational biochemistry protocol to evaluate the performance of six compounds (Lig783, Lig1022, Lig1392, Lig2177,
Desmond MacLeod-Carey, Eduardo Solis-Céspedes, Emilio Lamazares, Karel Mena-Ulecia   +3 more
doaj   +1 more source

Modulating Nitric Oxide Dioxygenase and Nitrite Reductase of Cytoglobin through Point Mutations

Antioxidants, 2022
Cytoglobin is a hexacoordinate hemoglobin with physiological roles that are not clearly understood. Previously proposed physiological functions include nitric oxide regulation, oxygen sensing, or/and protection against oxidative stress under hypoxic ...
John Ukeri, Michael T. Wilson, Brandon J. Reeder   +2 more
doaj   +1 more source

Cofactor Selectivity in Methylmalonyl Coenzyme A Mutase, a Model Cobamide-Dependent Enzyme. [PDF]

, 2019
Cobamides, a uniquely diverse family of enzyme cofactors related to vitamin B12, are produced exclusively by bacteria and archaea but used in all domains of life.
Mok, Kenny, Park, Jong, Quanstrom, Kathryn, Sokolovskaya, Olga, Taga, Michi, Tran, Jennifer   +5 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Factors affecting light energy transfer in some samarium complexes

International Journal of Photoenergy, 2005
The photophysical properties of samarium ion in presence of 7-Acetoxy Coumarin 3-Carboxylic acid (ACC) or 1-(4-methoxyphenyl) 3-(4-t-butyl phenyl) 1,3-propandione (MBPK), which act as antenna of near-UV radiation, are studied in different homogeneous ...
Esam Bakier, M. S. A. Abdel-Mottaleb
doaj   +1 more source