Results 81 to 90 of about 1,372,915 (271)

Hedgehog on the Move: Glypican-Regulated Transport and Gradient Formation in Drosophila

Cells
Glypicans (Glps) are a family of heparan sulphate proteoglycans that are attached to the outer plasma membrane leaflet of the producing cell by a glycosylphosphatidylinositol anchor.
Carlos Jiménez-Jiménez, Kay Grobe, Isabel Guerrero   +2 more
doaj   +1 more source

Neuropilin 1: A Novel Entry Factor for SARS-CoV-2 Infection and a Potential Therapeutic Target

Biologics: Targets & Therapy, 2021
Endeshaw Chekol Abebe,1 Teklie Mengie Ayele,2 Zelalem Tilahun Muche,3 Tadesse Asmamaw Dejenie4 1Department of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 2Department of Pharmacy, College of Health ...
Chekol Abebe E, Mengie Ayele T, Tilahun Muche Z, Asmamaw Dejenie T   +3 more
doaj  

^1H{^(19)F} NOE NMR Structural Signatures of the Insulin R_6 Hexamer: Evidence of a Capped HisB10 Site in Aryl- and Arylacryloyl-carboxylate Complexes [PDF]

, 2009
New and improved insulin: ^1H{^(19)F} NOE NMR difference spectra for CF_3-substituted aromatic carboxylates bound at the HisB10 sites of the R_6 human insulin (HI) hexamer show strong NOEs between the CF_3 groups and the LeuB6, AsnB3, and PheB1 ...
Bonaccio, Maria, Borchardt, Dan, Dunn, Michael F., Ghaderi, Nima, Keidel, Donald, Niks, Dimitri   +5 more
core  

Synthetic metallomolecules as agents for the control of DNA structure [PDF]

, 2007
This tutorial review summarises B-DNA structure and metallomolecule binding modes and illustrates some DNA structures induced by molecules containing metallic cations. The effects of aquated metal ions, cobalt amines, ruthenium octahedral metal complexes,
Adair D. Richards, Alessio, Alison Rodger, Baschnagel, Bierbach, Boulikas, Bragg, Brey, Browning, Carle, Chargaff, Clarke, Coggan, den Hartog, Eichhorn, Gale, Gessner, Goodsell, Guschlbauer, Hannon, Hannon, Haq, Hiort, Holliday, Humphrey, Khalid, Laine, Lerman, Lerman, Levitt, Liu, Loprete, Mainwaring, Manzotti, Marrington, Meistermann, Miescher, Molderheim, Neidle, Oleksi, Parkinson, Parkinson, Peberdy, Pelta, Rodger, Rodger, Rodger, Rodger, Rodger, Rosenberg, Sherman, Tabor, Ushay, Watson, Zou   +54 more
core   +1 more source

Establishing the entatic state in folding metallated Pseudomonas aeruginosa azurin [PDF]

, 2007
Understanding how the folding of proteins establishes their functional characteristics at the molecular level challenges both theorists and experimentalists.
Adman, Bryngelson, Bryngelson, C. J. Wilson, C. Zong, Crane, Frauenfelder, Gray, Malmstrom, Marks, Matouschek, Matouschek, Miyazawa, Nar, Nar, Onuchic, P. G. Wolynes, P. Wittung-Stafshede, Pozdnyakova, Ryde, S. L. Mayo, Solomon, T. Shen, Vallee, Williams, Winkler   +25 more
core   +3 more sources

Analysis of Binding Site Hot Spots on the Surface of Ras GTPase [PDF]

, 2011
We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers.
Buhrman, Greg, Kearney, Bradley M., Kovrigina, Elizaveta A., Kovriguine, Evgueni, Kozakov, Dima, Mattos, Carla, Napoleon, Raeanne, O\u27Connor, Casey, Vajda, Sandor, Zerbe, Brandon   +9 more
core   +2 more sources

Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach [PDF]

, 2008
BACKGROUND: Calmodulin is an important multifunctional molecule that regulates the activities of a large number of proteins in the cell. Calcium binding induces conformational transitions in calmodulin that make it specifically active to particular ...
Bates, Declan, Heslop-Harrison, Pat, Kotov, Nikolay, Postlethwaite, Ian, Valeyev, Najil   +4 more
core   +5 more sources

Short‐chain mono‐carboxylates as negative modulators of allosteric transitions in Gloeobacter violaceus ligand‐gated ion channel, and impact of a pre‐β5 strand (Loop Ω) double mutation on crotonate, not butyrate effect

Physiological Reports
Using the bacterial proton‐activated pentameric receptor‐channel Gloeobacter violaceus ligand‐gated ion channel (GLIC): (1) We characterize saturated, mono‐carboxylates as negative modulators of GLIC (as previously shown for crotonate; Alqazzaz et al ...
Catherine Van Renterghem, Ákos Nemecz, Karima Medjebeur, Pierre‐Jean Corringer   +3 more
doaj   +1 more source

The Metallo-β-lactamase GOB Is a Mono-Zn(II) Enzyme with a Novel Active Site [PDF]

, 2007
Metallo-β-lactamases (MβLs) are zinc-dependent enzymes able to hydrolyze and inactivate most β-lactam antibiotics. The large diversity of active site structures and metal content among MβLs from different sources has limited the design of a pan-MβL ...
Bennett, Brian, Carloni, Paolo, Costello, Alison L., Gonzalez, Javier M., Limansky, Adriana S., Lisa, Mariá Natalia, Morrán-Barrio, Jorgelina, Peraro, Matteo Dal, Tierney, David L., Viale, Alejandro M., Vila, Alejandro J.   +10 more
core   +1 more source

Origin and evolution of water oxidation before the last common ancestor of the Cyanobacteria [PDF]

, 2015
Photosystem II, the water oxidizing enzyme, altered the course of evolution by filling the atmosphere with oxygen. Here, we reconstruct the origin and evolution of water oxidation at an unprecedented level of detail by studying the phylogeny of all D1 ...
A. William Rutherford, Anisimova, Arato, Arnold, Bader, Beanland, Blankenship, Campbell, Cardona, Cardona, Chu, Chu, Clausen, Cox, Criscuolo, Cser, Dagan, Dau, Debus, Debus, Deusch, Diner, Dismukes, Erickson, Ferreira, Fine, Flannery, Gan, Gan, Giorgi, Gould, Gouy, Guindon, Gupta, Guskov, Hasegawa, Hillier, Hoganson, Hohmann-Marriott, Huson, Ishikita, Ishikita, James W. Murray, Jia, Johnson, Kiss, Klimov, Kopp, Koyama, Kulkarni, Kuroda, Lambreva, Larom, Larsson, Lartillot, Lee, Lidholm, Linke, Loll, Lyons, Marin, Merry, Metz, Michel, Michel, Mimuro, Muh, Mulo, Mulo, Murray, Murray, Nakamura, Nitschke, Nixon, Nixon, Nixon, Ochoa de Alda, Oettmeier, Ogami, Park, Petrouleas, Qian, Rappaport, Rasmussen, Raymond, Rippka, Robinson, Rodriguez-Ezpeleta, Roose, Rutherford, Rutherford, Saito, Sauer, Saw, Sedoud, Service, Shevela, Shi, Shih, Sicora, Sicora, Siegbahn, Sievers, Sugiura, Sugiura, Sugiura, Sugiura, Summerfield, Tanai Cardona, Tichy, Toepel, Turner, Ulas, Umena, Vass, Vassiliev, Vermaas, Vermaas, Vermaas, Vinyard, Waldbauer, Wegener, Yoon, Zehr, Zhang, Zhang, Zimmermann   +126 more
core   +1 more source