Results 91 to 100 of about 901,811 (316)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Ligand exchange reactions of [Re₂(μ-OR)₃(CO)₆]⁻(R = H, Me) with sulfur, selenium, phosphorus and nitrogen donor ligands, investigated by electrospray mass spectrometry

, 2000
Negative-ion electrospray mass spectrometry has been used to investigate the reactions of the dinuclear rhenium aggregates [Re₂(μ-OH)₃(CO)₆]⁻ 1 and [Re₂(μ-OMe)₃(CO)₆]⁻ 2 with a range of thiols, benzeneselenol, and some other sulfur-, phosphorus- and ...
Jiang, Chenghua, McCaffreyc, Louise J., Yan, Yaw Kai, Hor, T.S. Andy, McCaffrey, Louise J., Andy Hor, T. S., Van Kai, Yaw, Henderson, William   +7 more
core   +1 more source

The study of kinetic models for ligand exchange of anions as ligands using ligand-exchange resin

Journal of Applied Polymer Science, 1997
A comparative study of kinetic models for ligand exchange of I− Cl− and Br− Cl− as ligands as a function of pH and concentration using diaminoethyl-sporopollenin (DAE-sporopollenin) resin were investigated during the ligand-exchange reaction of the liquid phase.
Ersoz, M, Yigitoglu, M, Ayar, A
openaire   +3 more sources

The Nature of Ligand Efficiency [PDF]

Journal of Cheminformatics, 2018
Ligand efficiency is a widely used design parameter in drug discovery. It is calculated by scaling affinity by molecular size and has a nontrivial dependency on the concentration unit used to express affinity that stems from the inability of the logarithm function to take dimensioned arguments.
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

An investigation into the coordination chemistry of tripodal “click” triazole ligands with Mn, Ni, Co and Zn ions

, 2022
The steric influences of the triazole side chains in two tripodal chelating ligands tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine (TBTA) and tris[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]amine (TPTA) are explored through structural studies of four new ...
Chernobryva, Mariya, Hawes, Chris S., Watkinson, Michael, Motevalli, Majid   +3 more
core   +1 more source

Identification of a small‐molecule ligand of β‐arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells

Cancer Medicine, 2018
Stromal fibroblasts, which occupy a major portion of the tumor microenvironment, play an important role in cancer metastasis. Thus, targeting of these fibroblasts activated by cancer cells (carcinoma‐associated fibroblasts; CAFs) might aid in the ...
Kruthi Suvarna, Kaori Honda, Yasumitsu Kondoh, Hiroyuki Osada, Nobumoto Watanabe   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Iridium-catalyzed asymmetric hydrogenation of β-keto esters with new phenethylamine-derived tridentate P,N,N-ligands

, 2019
A new class of phenethylamine-derived tridentate P,N,N-ligands has been successfully developed. These ligands exhibited good performance in the Ir-catalyzed asymmetric hydrogenation of β-keto esters, affording the corresponding β-hydroxy esters in ...
Xiu-Shuai Chen (3341609), De-Quan Wei (6203240), Xiang-Ping Hu (1537561), Chuan-Jin Hou (2067520)   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source