Results 91 to 100 of about 1,019,350 (256)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Synthesis and characterization of gold(I) complexes of dibenzotropylidene-functionalized NHC ligands (Trop-NHCs) [PDF]

, 2014
The ERC (Advanced Investigator Award-FUNCAT), Syngenta, and the EPSRC are gratefully thanked for support of this work. S.P.N. is a Royal Society Wolfson Research Merit Award holder.Gold(I) complexes of dibenzotropylidene-functionalized N-heterocyclic ...
Slawin, Alexandra MZ, Alba Collado (1692373), Nolan, Steven Patrick, Cordes, David B, Alexandra M. Z. Slawin (809268), Collado, Alba, Collado-Martinez, Alba, David B. Cordes (1692379), Cordes, David Bradford, Brill, Marcel, Marcel Brill (1684192), Matthias Vogt (1692376), Slawin, Alexandra Martha Zoya, Vogt, Matthias, Gruetzmacher, Hansjoerg, Hansjörg Grützmacher (1519522), Steven P. Nolan (1489711), Nolan, Steven, Cordes, David B., Grützmacher, Hansjörg, Slawin, Alexandra M. Z., Nolan, Steven P., Slawin, Alexandra Martha Zoya; id_orcid, Cordes, David Bradford; id_orcid   +23 more
core   +1 more source

Chiral Tridentate-Based Ligands

, 2021
International audienceThe most recent tridentate ligands of any coordination pattern, which have been used in any reactions of asymmetric catalysis and which showed the greatest efficiencies in term of catalytic activities and selectivities, in ...
Sundararaju, Basker, Eric Manoury, Bandyopadhyay, Uchchhal, Uchchhal Bandyopadhyay, Poli, Rinaldo, Basker Sundararaju, Rinaldo Poli, Manoury, Eric   +7 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A New Type of Trimeric Formally Zerovalent Palladium Complexes only Supported by Nitrogen Ligands [PDF]

A New Type of Trimeric Formally Zerovalent Palladium Complexes only Supported by Nitrogen Ligands is ...
F. Ferretti, F. Ragaini, A. Dariol, P. Macchi   +3 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Chelating Properties of N₆O-Donors Toward Cu(II) Ions: Speciation in Aqueous Environments and Catalytic Activity of the Dinuclear Complexes

Molecules
This study focuses on the use of three isostructural N6O donor ligands, specifically known to form complexes with copper ions, to chelate Cu(II) from aqueous solutions.
Andrea Cendron, Martina Chianese, Kamil Zarzycki, Paolo Ruzza, Claudia Honisch, Justyna Brasuń, Mauro Carraro   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source