Results 131 to 140 of about 905,008 (316)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Synthesis of Transition Metal Complexes Supported by Mixed Donor PSiP' Bis-Phosphino Silyl Pincer Ligands [PDF]

, 2016
In an effort to explore new metal mediated reactivity and further the versatility of metal pincer chemistry, research in the Turculet group has targeted the synthesis of novel bis(phosphino)silyl PSiP pincer complexes.
Hoey, Marshall
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Marine-Derived Sterols from Saccharina japonica: Potential Antibacterial Activity and Target Prediction Against Bacterial Pathogens Through Integrated In Vitro and In Silico Approaches

Pathogens
Marine natural products, including seaweeds, sponges, and marine microorganisms, have emerged as promising sources of bioactive compounds with diverse pharmacological properties.
Eun-Seop Lee, Chae-Min Kim, Si-Heon Song, Su-Bin Jeon, Byeong-Su Kang, Md Sekendar Ali, Eon-Bee Lee   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Synthesis of Platinum Complexes Containing Bidentate N,O-donor Ligands [PDF]

, 2014
The reaction of N,O-donor ligands hippuric acid and N-phenylanthranilic acid with [PtCl₂(COD)] (COD = 1,5-cyclooctadiene) in dichloromethane and in the presence of silver(I) oxide yields the complexes [Pt{OC(O)CH₂N(COPh)}(COD)] and [Pt{OC(O)(C₆H₄)N(Ph ...
Sim, Sophie Anne
core  

Zinc(II) complexes of putative obligate tetrahedrally co-ordinating pro-ligands [PDF]

, 2014
An attempt to impose tetrahedral geometry on zinc() through use of bis(salicylideneamino)biphenyl pro-ligands has produced hydrolytically sensitive complexes.
Peter A. Tasker (1484926), Mary McPartlin (2190946), Joseph A. Connor (17188741), Achim Lienke (2481679), Domenico C. Cupertino (3058329), Michael Charlton (602247), Ian Scowen (17166964)   +6 more
core   +2 more sources

Expression of bone morphogenetic protein signaling pathway players in the jejunum and colon of adult rats

European Journal of Histochemistry
The bone morphogenetic protein (BMP) pathway, which plays a crucial role in the control of intestinal epithelial cell homeostasis, has been studied in mice and humans, leading to an understanding of its involvement in several intestinal pathologies ...
Emma Cogo, Edwin Fouché, Charline Buisson, Adenike Omotoyinbo, Fabrice Pierre, Françoise Guéraud, Pascale Plaisancié   +6 more
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

A New Type of Trimeric Formally Zerovalent Palladium Complexes only Supported by Nitrogen Ligands [PDF]

A New Type of Trimeric Formally Zerovalent Palladium Complexes only Supported by Nitrogen Ligands is ...
F. Ferretti, F. Ragaini, A. Dariol, P. Macchi   +3 more
core