Results 131 to 140 of about 5,237 (166)

CircRNA hsa_circ_0004781 promoted cell proliferation by acting as a sponge for miR-9-5p and miR-338-3p and upregulating KLF5 and ADAM17 expression in pancreatic ductal adenocarcinoma. [PDF]

Cancer Cell Int
Lee KL, Liu JJ, Huang WJ, Hung CS, Liang YC.   +4 more
europepmc   +1 more source

Circular RNAs: Novel Players in Cancer Mechanisms and Therapeutic Strategies. [PDF]

Int J Mol Sci
Kim J.
europepmc   +1 more source

The clinical potential of l-oligonucleotides: challenges and opportunities. [PDF]

Chem Sci
Shearer V, Yu CH, Han X, Sczepanski JT.
europepmc   +1 more source

Exploring RNA modifications in infectious non-coding circular RNAs. [PDF]

RNA Biol
Vopalensky P, Škríba A, Chiumenti M, Ďuričeková L, Šimonová A, Lukšan O, Di Serio F, Navarro B, Cahova H.   +8 more
europepmc   +1 more source

Long-read transcriptome-wide RNA structure maps using DMS-FIRST-seq

Begik O, Diensthuber G, Borovska I, Mattick JS, Incarnato D, Novoa EM.   +5 more
europepmc   +1 more source

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Application of RtcB ligase to monitor self-cleaving ribozyme activity by RNA-seq

Biological Chemistry, 2022
Abstract Self-cleaving ribozymes are catalytic RNAs and can be found in all domains of life. They catalyze a site-specific cleavage that results in a 5′ fragment with a 2′,3′ cyclic phosphate (2′,3′ cP) and a 3′ fragment with a 5′ hydroxyl (5′ OH) end. Recently, several strategies to enrich self-cleaving ribozymes by targeted biochemical
V. Janett Olzog, Lena I. Freist, Robin Goldmann, Jörg Fallmann, Christina E. Weinberg   +4 more
openaire   +2 more sources

In vitro Selection of Ligase Ribozymes Containing 2'-Amino Groups

Journal of Bioactive and Compatible Polymers, 2000
Novel ribozymes containing 2'-amino groups in the side chains were in vitro selected to accelerate their ligation reaction rates with oligodeoxynucleotides. The ligation rate of random sequenced RNAs in the starting pool was accelerated by incorporation of 2'-amino-2'-deoxyuridine and N6-(6-aminohexyl)adenosine.
Yukio Imanishi, Yoshihiro Ito, Naozumi Teramoto   +2 more
openaire   +2 more sources

Artificial Ligase Ribozymes Isolated by a “Design and Selection” Strategy

2015
We developed a new in vitro selection strategy "design and selection" to isolate effectively artificial ribozymes (catalytic RNAs). An overall RNA structure (scaffold) is initially designed, and then a relatively short randomized sequence is installed at the reaction point of the scaffold, followed by the in vitro selection.
Yoshiya Ikawa, Shigeyoshi Matsumura
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Expanded divalent metal-ion tolerance of evolved ligase ribozymes

Biochimie, 2003
Class I ligases are artificial ribozymes that catalyze the joining of two single-stranded RNAs. These ribozymes are between 120 and 160 nucleotides in length, making them intermediate in size for catalytic RNAs. Previous characterization of the b1-207 ribozyme suggests that it behaves similar to larger ribozymes in terms of divalent metal-ion ...
Craig A. Riley, Niles Lehman
openaire   +3 more sources

In Vitro Selection of a Ligase Ribozyme Carrying Alkylamino Groups in the Side Chains

Bioconjugate Chemistry, 2000
A novel ligase ribozyme was in vitro selected from a random-sequence RNA library including N(6)-aminohexyl-modified adenine residues in place of natural adenine residues. This ribozyme mediated the formation of a phosphodiester bond with a DNA oligonucleotide through condensation with a 5'-triphosphate moiety on the ribozyme.
Yukio Imanishi, Yoshihiro Ito, Naozumi Teramoto   +2 more
openaire   +3 more sources