Results 51 to 60 of about 5,237 (166)
Selective Nonenzymatic Formation of Biologically Common RNA Hairpins
Angewandte Chemie, Volume 137, Issue 5, January 27, 2025.Template‐free RNA loop‐closing ligation selectively generates RNA tetraloops that are prevalent in biology, as demonstrated by high‐throughput sequencing. Utilizing high‐yield overhang sequences enables the efficient assembly of functional RNAs. Abstract The prebiotic formation of RNA building blocks is well‐supported experimentally, yet the emergence ...
Long‐Fei Wu +5 more
wiley +2 more sources
In vitro Evolution and Engineering for Improved Ribozyme Polymerase Production [PDF]
, 2011 According to the "RNA World Hypothesis" the first self replicating molecule formed from the prebiotic chemicals is the ribozyme. A model compartmentalized self replicating system for ribozyme polymerases is designed and used to improve activity,
Ayaz Ali Khan +2 more
core +1 more source
Man versus Machine versus Ribozyme [PDF]
, 2008 A microfluidic device has been constructed to carry out the automated, continuous evolution of ribozymes.
Andrew D Ellington +12 more
core +3 more sources
RETRACTED: Replication of an RNA ligase ribozyme under alternating temperature condition [PDF]
FEBS Letters, 2007 Felix Wieland, Managing ...
Woo-Hyung Choi +6 more
openaire +2 more sources
Ribozyme Diagnostics Comes of Age [PDF]
, 2004 Biosensing ribozymes could soon be used to diagnose viral infection. The Kossen group from Sirna Therapeutics have developed a sensitive, high-throughput means of screening for hepatitis C virus, using their target activated half-ribozyme technology, as ...
Rossi, John J
core +1 more source
Continuous In Vitro evolution of a ribozyme ligase: A model experiment for the evolution of a biomolecule [PDF]
Biochemistry and Molecular Biology Education, 2013 AbstractEvolution is a defining criterion of life and is central to understanding biological systems. However, the timescale of evolutionary shifts in phenotype limits most classroom evolution experiments to simple probability simulations. In vitro directed evolution (IVDE) frequently serves as a model system for the study of Darwinian evolution but ...
Michael P. Ledbetter +3 more
openaire +3 more sources
Genotype Network Intersections Promote Evolutionary Innovation [PDF]
, 2019 Evolutionary innovations are qualitatively novel traits that emerge through evolution and increase biodiversity. The genetic mechanisms of innovation remain poorly understood.
Bendixsen, Devin P. +3 more
core +2 more sources
Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy
ChemPlusChem, EarlyView.Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber +3 more
wiley +1 more source
Probing RNA catalysis in protocellular settings relevant to the origin of life [PDF]
, 2023 The emergence of life has long been a topic of high interest. Of the many hypotheses pro-posed for the emergence of early cellular predecessors of our last universal common ances-tor (LUCA), the RNA World hypothesis is a prime candidate. It posits a time
Salibi, Elia
core
Exploring the Potential and Advancements of Circular RNA Therapeutics
Exploration, EarlyView.Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang +6 more
wiley +1 more source