Viroids: Survivors from the RNA World? [PDF]
, 2014 Because RNA can be a carrier of genetic information and a biocatalyst, there is a consensus that it emerged before DNA and proteins, which eventually assumed these roles and relegated RNA to intermediate functions.
Flores, Ricardo +3 more
core +1 more source
Biology Direct, 2007 Background The origin of the translation system is, arguably, the central and the hardest problem in the study of the origin of life, and one of the hardest in all evolutionary biology.
Koonin Eugene V, Wolf Yuri I
doaj +1 more source
Large Phenotypic Enhancement of Structured Random RNA Pools. [PDF]
, 2020 Laboratory evolution of functional RNAs has applications in many areas of chemical and synthetic biology. In vitro selections critically depend on the presence of functional molecules, such as aptamers and ribozymes, in the starting sequence pools.
Chizzolini, Fabio +5 more
core
Metal Ion Requirements for Structure and Catalysis of an RNA Ligase Ribozyme [PDF]
Biochemistry, 2002 The class I ligase, a ribozyme previously isolated from random sequence, catalyzes a reaction similar to RNA polymerization, positioning its 5'-nucleotide via a Watson-Crick base pair, forming a 3',5'-phosphodiester bond between its 5'-nucleotide and the substrate, and releasing pyrophosphate.
Margaret E, Glasner +2 more
openaire +2 more sources
Synthetic shuffling and in vitro selection reveal the rugged adaptive fitness landscape of a kinase ribozyme [PDF]
, 2012 The relationship between genotype and phenotype is often described as an adaptive fitness landscape. In this study, we used a combination of recombination, in vitro selection, and comparative sequence analysis to characterize the fitness landscape of a ...
Bartel, David, Curtis, Edward A.
core +1 more source
Rolling-circle replication of viroids, viroid-like satellite RNAs and hepatitis delta virus: variations on a theme [PDF]
, 1999 Viroids and viroid-like satellite RNAs from plants, and the human hepatitis delta virus (HDV) RNA share some properties that include small size, circularity and replication through a rolling-circle mechanism.
Flores, Ricardo +5 more
core +1 more source
Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit
Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.A modular RNA‐based sonogenetic toolkit enables remote control of gene expression in eukaryotes by releasing small molecule modulators from ultrasound‐responsive carriers. These modulators activate engineered mRNA elements such as riboswitches, leading to tunable protein expression.
Fahimeh Charbgoo +7 more
wiley +2 more sources
Chemical fidelity of an RNA polymerase ribozyme [PDF]
, 2013 The emergence of catalytically active RNA enzymes (ribozymes) is widely believed to have been an important transition in the origin of life. In the context of a likely heterogeneous chemical environment, substrate specificity and selectivity of these ...
Attwater, J. +8 more
core +1 more source
RETRACTED: Replication of an RNA ligase ribozyme under alternating temperature condition [PDF]
FEBS Letters, 2007 Felix Wieland, Managing ...
Kim, Ki-Sun +6 more
openaire +1 more source
In vitro Evolution and Engineering for Improved Ribozyme Polymerase Production [PDF]
, 2011 According to the "RNA World Hypothesis" the first self replicating molecule formed from the prebiotic chemicals is the ribozyme. A model compartmentalized self replicating system for ribozyme polymerases is designed and used to improve activity,
Ayaz Ali Khan +2 more
core +1 more source