Results 71 to 80 of about 5,436 (190)
A fast, efficient and sequence-independent method for flexible multiple segmental isotope labeling of RNA using ribozyme and RNase H cleavage [PDF]
, 2017 Structural information on RNA, emerging more and more as a major regulator in gene expression, dramatically lags behind compared with information on proteins.
Allain, Frédéric H.-T +3 more
core
Effective suppression of Dengue virus using a novel group-I intron that induces apoptotic cell death upon infection through conditional expression of the Bax C-terminal domain [PDF]
, 2014 Introduction: Approximately 100 million confirmed infections and 20,000 deaths are caused by Dengue virus (DENV) outbreaks annually. Global warming and rapid dispersal have resulted in DENV epidemics in formally non-endemic regions.
Carter, James R. +7 more
core +1 more source
Structural Biology of RNA and Protein‐RNA Complexes after AlphaFold3
ChemBioChem, Volume 26, Issue 7, April 1, 2025.AlphaFold is a great research accelerator and hypothesis generator for structural biology and beyond. With the release of AlphaFold3, RNA and protein‐RNA complex structure prediction is readily possible. This review assesses the reliability of these predictions.
Janosch Hennig
wiley +1 more source
The 2'-5' RNA Ligase of Escherichia coli: Purification, Cloning, and Genomic Disruption [PDF]
, 1996 An RNA ligase previously detected in extracts of Escherichia coli is capable of joining Saccharomyces cerevisiae tRNA splicing intermediates in the absence of ATP to form a 2-5 phosphodiester linkage (Greer, C., Javor, B., and Abelson, J. (1983) Cell 33,
Abelson, John N., Arn, Eric A.
core
Escalation of error catastrophe for enzymatic self-replicators [PDF]
, 2007 It is a long-standing question in origin-of-life research whether the information content of replicating molecules can be maintained in the presence of replication errors.
B. Obermayer +5 more
core +2 more sources
Decoupling Activity and Specificity in Coronazymes
Small, Volume 21, Issue 14, April 9, 2025.A new Au nanoparticle (AuNP) based nanozyme, aptamer–coronazyme, which demonstrates ≈30 times higher activity on d‐glucose than the pristine AuNP nanozymes, is designed and characterized. This coronazyme shows long‐range chiral specificity controlled by circularly polarized lights and catalytic reactivity modulated by short‐range intermolecular forces.
Jiahao Ji +6 more
wiley +1 more source
Small, Volume 21, Issue 9, March 5, 2025.Microfluidic‐based directed evolution is a powerful tool for selection of biopolymers, however they struggle in transferability to intracellular environments. The “biomimetic equivalence” principle provides a versatile and practical framework for developing biopolymers that function effectively in cells using a cell‐free approach.
Andrew Brian Kinghorn +10 more
wiley +1 more source
The dynamics of the RNA world : Insights and challenges [PDF]
, 2015 The problem of the origin of life is not only one of structure but also that of dynamics. Ever since the seminal result of Manfred Eigen in 1971 showing that early template replication suffers from an error threshold, research has tackled the issue of ...
Boza, Gergely +5 more
core +4 more sources
Physiologia Plantarum, Volume 177, Issue 2, March/April 2025.Abstract Viral infections are major contributors to crop yield loss and represent a significant threat to sustainable agriculture. Plants respond to virus attacks by activating sophisticated signalling cascades that initiate multiple defence mechanisms.
Kritika Shukla +4 more
wiley +1 more source
RNA self-cleavage activated by ultraviolet light-induced oxidation [PDF]
, 2012 A novel UV-C-light-induced ribozyme activity was discovered within the highly structured 5′-genomic regions of both Hepatitis C Virus (HCV) and the related Classic Swine Fever Virus (CSFV).
Ariza-Mateos, Ascensión +7 more
core +2 more sources