Results 101 to 110 of about 143,768 (336)

Ubiquitin ligases: guardians of mammalian development

Nature reviews. Molecular cell biology, 2022
D. A. Cruz Walma, Zhuoyao Chen, A. Bullock, Kenneth M. Yamada   +3 more
semanticscholar   +1 more source

A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein

Scientific Reports, 2019
Asparaginyl endopeptidases (AEPs) are a class of enzymes commonly associated with proteolysis in the maturation of seed storage proteins. However, a subset of AEPs work preferentially as peptide ligases, coupling release of a leaving group to formation ...
K. Harris, R. Guarino, Ravindu S. Dissanayake, Pedro Quimbar, Owen McCorkelle, S. Poon, Q. Kaas, T. Durek, E. Gilding, M. Jackson, D. Craik, N. L. van der Weerden, R. Anders, M. Anderson   +13 more
semanticscholar   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase [PDF]

, 2023
Nicholas Purser, Ishita Tripathi‐Giesgen, Jerry Li, Daniel C. Scott, Daniel Horn‐Ghetko, Kheewoong Baek, Brenda A. Schulman, Arno F. Alpi, Gary Kleiger   +8 more
openalex   +1 more source

Flavin Biosynthesis Enhances Extracellular Electron Transfer in Bioengineered Escherichia coli

Advanced Science, EarlyView.
Microbial electronics are promising for energy, sensing, environmental, and synthesis applications. E. coli are engineered with extracellular electron transfer (EET) pathways from a microbe that naturally produces current to enable bioelectronics based on E. coli.
Mohammed Mouhib, Melania Reggente, Hanxuan Wang, Charlotte Roullier, Ardemis A. Boghossian   +4 more
wiley   +1 more source

Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases

Frontiers in Physiology, 2019
Mitochondria are dynamic organelles engaged in quality control and aging processes. They constantly undergo fusion, fission, transport, and anchoring events, which empower mitochondria with a very interactive behavior.
M. Escobar-Henriques, Mariana Joaquim
semanticscholar   +1 more source

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

Advances of E3 ligases in lung cancer

Biochemistry and Biophysics Reports
Lung cancer is a leading cause of cancer-related death, and the most common type of lung cancer is non-small cell lung cancer, which accounts for approximately 85 % of lung cancer diagnoses.
Jingwen Yu, Yiqi Zhao, Yue Xie
doaj   +1 more source

E3 ubiquitin ligases and plant innate immunity [PDF]

, 2009
Andrew W. Craig, Richard Ewan, Joelle Mesmar, Venugopal Gudipati, Ari Sadanandom   +4 more
openalex   +1 more source

Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response [PDF]

, 2020
Mei Song, Chao Wang, Huan Wang, Tuo Zhang, Jiuqi Li, Robert Benezra, Lotfi Chouchane, Yinhao Sun, Xingang Cui, Xiaojing Ma   +9 more
openalex   +1 more source