Results 251 to 260 of about 143,768 (336)
Advanced Science, EarlyView.A tunable, ethylene‐responsive cascade governing the dose‐dependent balance between fiber length and strength is unveiled. Elevated ethylene strengthens modern tetraploid cotton (G. hirsutum) fibers but elongates those of its diploid ancestor (G. arboreum). This phenotypic switch is traced to an evolutionary functional inversion of a conserved EIN3‐ERF‐
Jie Zhang +10 more
wiley +1 more source
Targeting the Ubiquitin-Proteasome System for Cancer. [PDF]
MedComm (2020)Liu Z, Lai J, Ma Z, Pan J, Yang C, Fu R.
europepmc +1 more source
Advanced Science, EarlyView.In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang +19 more
wiley +1 more source
Targeted Protein Degradation for Agricultural Applications: Rationale, Challenges, and Outlook. [PDF]
ACS Bio Med Chem AuFourches D +4 more
europepmc +1 more source
GSK3β‐Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy
Advanced Science, EarlyView.Uterine Gsk3b knockout impairs decidual cell terminal differentiation by causing lipid droplet accumulation. GSK3β phosphorylates RNF213 to promote its lysosomal degradation, thereby enhancing lipolysis. The released fatty acids undergo β‐oxidation to generate acetyl‐CoA, which modulates histone acetylation and regulates decidual cell terminal ...
Peiran Wang +14 more
wiley +1 more source
Deubiquitinase-Targeting Chimeras Mediated Stabilization of Tumor Suppressive E3 Ligase Proteins as a Strategy for Cancer Therapy. [PDF]
J Am Chem SocChen L +11 more
europepmc +1 more source
Advanced Science, EarlyView.These findings elucidated the crucial role of the “SVs‐3D genome remodeling‐epigenetic modifications‐gene expression” cascade regulatory network in cotton fiber domestication, offering both a theoretical foundation and genetic resources for molecular design breeding in fiber crops.
Lei Shao +11 more
wiley +1 more source
Sumoylation of cyclin and its therapeutic potential for cancer. [PDF]
Anim Cells Syst (Seoul)Ryu HY, Hochstrasser M.
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A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β
Advanced Science, EarlyView.This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo +12 more
wiley +1 more source