Results 21 to 30 of about 120,350 (347)

Progress on Poxvirus E3 Ubiquitin Ligases and Adaptor Proteins

open access: yesFrontiers in Immunology, 2021
Poxviruses have evolved a variety of innate immunity evasion mechanisms, some of which involve poxvirus-encoded E3 ubiquitin ligases and adaptor proteins.
Haoran Cui   +7 more
doaj   +1 more source

Expanding PROTACtable genome universe of E3 ligases

open access: yesNature Communications, 2023
Proteolysis-targeting chimera (PROTAC) and other targeted protein degradation (TPD) molecules that induce degradation by the ubiquitin-proteasome system (UPS) offer new opportunities to engage targets that remain challenging to be inhibited by ...
Yuan Liu   +9 more
doaj   +1 more source

Ubiquitin Ligases at the Heart of Skeletal Muscle Atrophy Control

open access: yesMolecules, 2021
Skeletal muscle loss is a detrimental side-effect of numerous chronic diseases that dramatically increases mortality and morbidity. The alteration of protein homeostasis is generally due to increased protein breakdown while, protein synthesis may also be
Dulce Peris-Moreno   +4 more
doaj   +1 more source

DNA Ligase I, the Replicative DNA Ligase [PDF]

open access: yes, 2012
Multiple DNA ligation events are required to join the Okazaki fragments generated during lagging strand DNA synthesis. In eukaryotes, this is primarily carried out by members of the DNA ligase I family. The C-terminal catalytic region of these enzymes is composed of three domains: a DNA binding domain, an adenylation domain and an OB-fold domain.
Timothy R.L. Howes, Alan E. Tomkinson
openaire   +3 more sources

The role of Schizosaccharomyces pombe SUMO ligases in genome stability [PDF]

open access: yes, 2007
SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is ...
A. Skilton   +44 more
core   +2 more sources

Ubiquitin-protein ligases [PDF]

open access: yesJournal of Cell Science, 2004
Post-translational covalent tagging of proteins with the 76-residue protein ubiquitin (Ub) serves many functions. Polyubiquitylated proteins are directed to the large multi-component, multi-catalytic protease the 26S proteasome.
Philip A. Robinson, H. C. Ardley
openaire   +3 more sources

E3-ligase knock down revealed differential titin degradation by autopagy and the ubiquitin proteasome system

open access: yesScientific Reports, 2021
The sarcomere protein titin is a major determinant of cardiomyocyte stiffness and ventricular distensibility. The constant mechanical stress on titin requires well-controlled protein quality control, the exact mechanisms of which have not yet been fully ...
Erik Müller   +5 more
doaj   +1 more source

RBR E3 ubiquitin ligases: new structures, new insights, new questions [PDF]

open access: yes, 2014
The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes.
Shaw, Gary S.   +2 more
core   +1 more source

E3 Ubiquitin Ligases as Cancer Targets and Biomarkers

open access: yesNeoplasia: An International Journal for Oncology Research, 2006
E3 ubiquitin ligases are a large family of proteins that are engaged in the regulation of the turnover and activity of many target proteins. Together with ubiquitinactivating enzyme El and ubiquitin-conjugating enzyme E2, E3 ubiquitin ligases catalyze ...
Yi Sun
doaj   +1 more source

Targeted Degradation of 53BP1 Using Ubiquitin Variant Induced Proximity

open access: yesBiomolecules, 2022
In recent years, researchers have leveraged the ubiquitin-proteasome system (UPS) to induce selective degradation of proteins by E3 ubiquitin ligases, which has great potential as novel therapeutics for human diseases, including cancer and ...
Bayonle Aminu   +4 more
doaj   +1 more source

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