Results 21 to 30 of about 195 (168)

Comparative Study of Pleural Fluid-to-serum Bilirubin Ratio and Light’s Criteria in Differentiating Exudative from Transudative Pleural Effusion

Journal of Applied Sciences and Clinical Practice
Introduction: Pleural effusion is a common diagnostic problem associated with significant morbidity. Its management mainly depends on the correct diagnosis of underlying disease.
Ramulu Gaddam, Veena Vankayala, Monica Jonnalagadda, Manasa Musku, Phani Bhushan Gurumurthy, M. G. Krishna Murthy, Manchala Shree Swathhy   +6 more
doaj   +1 more source

Diagnostic utility of pleural fluid/serum bilirubin ratio versus light’s criteria in differentiating exudative and transudative pleural effusions. A cross-sectional observational study.

Student's Journal of Health Research Africa
Background Differentiation between exudative and transudative pleural effusions is fundamental for guiding clinical management. Light’s criteria remain the standard, though reports suggest misclassification in certain cases, necessitating exploration of
Dr. Jonnalagadda Monika , Dr. S Deepan Raj , Dr. Beera Nithin Joseph , Dr.Perapagu Jhansi   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Cut-off value of pleural fluid C-reactive protein in etiologic diagnosis of pleural fluid

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Background: Classification of effusion into transudates or exudates is considered as the corner stone in the etiological diagnosis of pleural effusion.
Mona Mansour Ahmed, Hesham A. Abdelhalim, Nora A.H. El Kholy   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Hepatic Hydrothorax without Apparent Ascites and Dyspnea - A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2018
A 78-year-old female with a past medical history of alcoholic cirrhosis was hospitalised with recurrent lower gastrointestinal bleeding due to rectal ulcers. The ulcers were successfully treated with cautery and placement of clips.
Jing He, Rasha Haykal, Hongchuan Coville, Jaya Prakash Gadikota, Christopher Bray   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Revisiting Light's criteria: a validated blood-free triple combination matches diagnostic accuracy in over 7000 patients

ERJ Open Research
Background Light's criteria remain the standard for distinguishing exudative from transudative pleural effusions, but require serum sampling and lack specificity.
José M. Porcel, Laura Porcel, Rosa Palma, Silvia Bielsa   +3 more
doaj   +1 more source