Results 71 to 80 of about 5,896 (278)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Pediatric pleural tuberculosis

International Journal of Mycobacteriology, 2018
Background: Pleural tuberculosis (TB) diagnosis is sometimes controversial because the microbiologic confirmation ratio is very low in pleural fluid. There are few pediatric pleural TB case series in the literature.
Gulsum Iclal Bayhan, Fuat Sayir, Gonul Tanir, Oguz Tuncer   +3 more
doaj   +1 more source

تعيين ارزش تشخيصی نسبت کلسترول و بيلی‌روبين مايع پلور به سرم در تعيين نوع افيوژن پلور [PDF]

, 2002
نخستين گام در راه تشخيص علت مايع جنبی جدانمودن موارد اگزودا از ترانسودا می‌باشد. در اين راستا معيار Light سالها مورد استفاده قرار گرفته است، ولی گاهی مقادير پروتئين و LDH مايع جنبی در محدوده مرزی قرار می‌گيرند و لذا استفاده از ميزان ديگر مواد موجود در ...
احتشامی‌افشار, امین, امام‌زادگان, رامین, رضائيان, مرتضی, زحمتکش, محمدمهدی, چهرئی, علی   +4 more
core  

The Dwarf Spheroidal Companions to M31: WFPC2 Observations of Andromeda I [PDF]

, 1996
Images have been obtained with the Hubble Space Telescope WFPC2 camera of Andromeda I, a dwarf spheroidal (dSph) galaxy that lies in the outer halo of M31.
Armandroff, T. E., Caldwell, Nelson, Da Costa, G. S., Seitzer, Patrick   +3 more
core   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Large Scale Earth's Bow Shock with Northern IMF as simulated by PIC code in parallel with MHD model

, 2016
In this paper, we propose a 3D kinetic model (Particle-in-Cell PIC ) for the description of the large scale Earth's bow shock. The proposed version is stable and does not require huge or extensive computer resources.
Baraka, Suleiman M
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Pleural fluid characteristics of patients with COVID‐19 infection

The Clinical Respiratory Journal
Introduction Pleural effusions are known to occur in many cases of COVID‐19. Data on typical characteristics of COVID‐19‐associated pleural effusions are limited. The goal of this project was to characterize the pleural fluid from patients with COVID‐19.
Ryan A. Denu, Victoria Forth, Majid Shafiq   +2 more
doaj   +1 more source

Evaluation of the performance of biochemical ratios and albumin’s gradient in the etiological exploration of ascitic fluid

Journal de la Faculté de Médecine d'Oran
Introduction Biochemical exploration of effusion fluids plays a crucial role in the diagnosis of underlying pathologies. This study aimed to evaluate the performance of biochemical ratios and the albumin gradients in the diagnostic process of ascitic
Mourad Nachi, Ibtissem Kihel, Yousra Meguenni, Zineb Tahiri, Nazim Korti   +4 more
doaj   +1 more source