Results 51 to 60 of about 5,896 (278)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Role of pleural fluid-serum protein carbonyl gradient in differentiating exudative and transudative effusions

Asian Journal of Medical Sciences, 2020
Background: Pleural effusions often cause a diagnostic dilemma. The first step in the evaluation of pleural effusions is the distinction between exudates and transudates.
Raghumoy Ghosh , Kheya Mukherjee , Saumyajit Maiti , Debojyoti Bhattacharjee , Shubho Chowdhuri   +4 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Estimation of Exoplanetary Planet-to-Star Radius Ratio with Homomorphic Processing

, 2017
In this paper a homomorphic filtering scheme is proposed to improve the estimation of the planet/star radius ratio in astronomical transit signals. The idea is to reduce the effect of the short-term earth atmosphere variations.
Firoozabadi, Ali Dehghan, Mahu, Rodrigo, Rojo, Patricio, Sedaghati, Elyar, Soto, Ismael, Yoma, Nestor Becerra   +5 more
core   +1 more source

Interacting galaxies and cosmological parameters [PDF]

, 2006
We propose a (physical)-geometrical method to measure the present rates of the density cosmological parameters for a Friedmann-Lemaitre universe. The distribution of linear separations between two interacting galaxies,when both of them undergo a first ...
Barnes, Berger, Blanchard, Chen, Croom, Dashveski, Demianski, Djorgovski, Dyer, Goldhabber, Guerra, Gurvits, H. Reboul, J.-P. Cordoni, Kellermann, Le Fèvre, Lemaître, Lima, Mihos, Reboul, Reboul, Remijan, Riess, Robertson, Sahni, Sanders, Schmidt, Springel, Steidel, Tolman, Toomre, Vanderriest, Véron, Zhu, Zhu, Zhu   +35 more
core   +6 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Application of Computed Tomography (CT) Attenuation Values in Diagnosis of Transudate and Exudate in Patients with Pleural Effusion

Journal of Gandaki Medical College, 2018
Background: Pleural effusion is the pathologic accumulation of fluid in the pleural space. The fluid analysis yields important diagnostic information, and in certain cases, fluid analysis alone is enough for diagnosis.
Keshab Sharma, PS Lamichhane, BK Sharma
doaj   +1 more source

Constant Optical Power Operation of an Ultraviolet LED Controlled by a Smartphone

Sensors, 2021
Constant light power operation of an ultraviolet (UV) LED based on portable low-cost instrumentation and a monolithically integrated monitoring photodiode (MPD) has been reported for the first time.
Ching-Hua Chen, Jia-Jun Zhang, Chang-Han Wang, Yu-Chia Chang, Pinghui S. Yeh   +4 more
doaj   +1 more source